human, Cynomolgus/ Rhesus macaque, rat, mouse Tumor necrosis factor receptor superfamily, member 1A(TNFRSF1A) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.


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Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse Tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Tumor necrosis factor receptor 1 (TNFR1), also known as tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) and CD120a, is a ubiquitous membrane receptor that binds tumor necrosis factor-alpha (TNFα). protein encoded by this gene is a member of the tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor.


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Catalog No.Product NameAntigen: Species
Antibody: Species Reactivity		SizePrice
GM-Tg-hg-T86552-Ag-1Tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A) proteinhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T86552-Ab-1Anti-TNFRSF1A monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T86552-Ab-2Anti-TNFRSF1A monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T86552-Ag-1Tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A)rat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T86552-Ab-1Anti-TNFRSF1A monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T86552-Ab-2Anti-TNFRSF1A monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T86552-Ag-1Tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A)mouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T86552-Ab-1Anti-TNFRSF1A monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T86552-Ab-2Anti-TNFRSF1A monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T86552-Ag-1Tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A)Cynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T86552-Ab-1Anti-TNFRSF1A monoclonal antibodyCynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T86552-Ab-2Anti-TNFRSF1A monoclonal antibodyCynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

Description


Target Information

Target NameTNFRSF1A
Full nameTumor necrosis factor receptor superfamily, member 1A
Gene ID7132
Gene NameTNFRSF1A
Gene AliasCD120a, FPF, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR55, TNFR60, p55, p55-R, p60
Protein Sub-locationTransmembrane Protein

Antigen Information

Cat No.GM-Tg-hg-T86552-Ag-1, GM-Tg-rg-T86552-Ag-1, GM-Tg-mg-T86552-Ag-1, GM-Tg-cynog-T86552-Ag-1
Products NameTumor necrosis factor receptor superfamily, member 1A (TNFRSF1A) protein
Specieshuman, Cynomolgus/ Rhesus macaque, rat, mouse
IsotypesRecombinant protein
Expression platformMammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated
TagHis
Product DescriptionRecombinant human, Cynomolgus/ Rhesus macaque, rat, mouse Tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
ApplicationCell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis.
Formulation & ReconstitutionLyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.GM-Tg-hg-T86552-Ab-1, GM-Tg-hg-T86552-Ab-2,
GM-Tg-rg-T86552-Ab-1, GM-Tg-rg-T86552-Ab-2,
GM-Tg-mg-T86552-Ab-1, GM-Tg-mg-T86552-Ab-2,
GM-Tg-cynog-T86552-Ab-1, GM-Tg-cynog-T86552-Ab-2
Products NameAnti-TNF-R1/TNFRSF1A monoclonal antibody
Formatmab
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
Species ReactivityHuman(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m)
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TNF-R1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.