human, Cynomolgus/ Rhesus macaque, rat, mouse cysteine-rich, angiogenic inducer, 61(CYR61) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.


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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse cysteine-rich, angiogenic inducer, 61 (CYR61) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Cysteine-rich angiogenic inducer 61 (CYR61) or CCN family member 1 (CCN1), is a matricellular protein that in humans is encoded by the CYR61 gene. CYR61 is a secreted, extracellular matrix (ECM)-associated signaling protein of the CCN family (CCN intercellular signaling protein). CYR61 is capable of regulating a broad range of cellular activities, including cell adhesion, migration, proliferation, differentiation, apoptosis, and senescence through interaction with cell surface integrin receptors and heparan sulfate proteoglycans. During embryonic development, CYR61 is critical for cardiac septal morphogenesis, blood vessel formation in placenta, and vascular integrity. In adulthood CYR61 plays important roles in inflammation and tissue repair, and is associated with diseases related to chronic inflammation, including rheumatoid arthritis, atherosclerosis, diabetes-related nephropathy and retinopathy, and many different forms of cancers.


Order information


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Catalog No.Product NameAntigen: Species
Antibody: Species Reactivity		SizePrice
GM-Tg-hg-T85289-Ag-1cysteine-rich, angiogenic inducer, 61 (CYR61) proteinhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T85289-Ab-1Anti-CYR61 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T85289-Ab-2Anti-CYR61 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T85289-Ag-1cysteine-rich, angiogenic inducer, 61 (CYR61)rat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T85289-Ab-1Anti-CYR61 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T85289-Ab-2Anti-CYR61 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T85289-Ag-1cysteine-rich, angiogenic inducer, 61 (CYR61)mouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T85289-Ab-1Anti-CYR61 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T85289-Ab-2Anti-CYR61 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T85289-Ag-1cysteine-rich, angiogenic inducer, 61 (CYR61)Cynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T85289-Ab-1Anti-CYR61 monoclonal antibodyCynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T85289-Ab-2Anti-CYR61 monoclonal antibodyCynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

Description


Target Information

Target NameCYR61
Full namecysteine-rich, angiogenic inducer, 61
Gene ID3491
Gene NameCYR61
Gene AliasCYR61, GIG1, IGFBP10
Protein Sub-locationSecreted Protein/Potential Cytokines

Antigen Information

Cat No.GM-Tg-hg-T85289-Ag-1, GM-Tg-rg-T85289-Ag-1, GM-Tg-mg-T85289-Ag-1, GM-Tg-cynog-T85289-Ag-1
Products Namecysteine-rich, angiogenic inducer, 61 (CYR61) protein
Specieshuman, Cynomolgus/ Rhesus macaque, rat, mouse
IsotypesRecombinant protein
Expression platformMammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated
TagHis
Product DescriptionRecombinant human, Cynomolgus/ Rhesus macaque, rat, mouse cysteine-rich, angiogenic inducer, 61 (CYR61) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
ApplicationCell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis.
Formulation & ReconstitutionLyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.GM-Tg-hg-T85289-Ab-1, GM-Tg-hg-T85289-Ab-2,
GM-Tg-rg-T85289-Ab-1, GM-Tg-rg-T85289-Ab-2,
GM-Tg-mg-T85289-Ab-1, GM-Tg-mg-T85289-Ab-2,
GM-Tg-cynog-T85289-Ab-1, GM-Tg-cynog-T85289-Ab-2
Products NameAnti-CYR61/CCN1 monoclonal antibody
Formatmab
Category of antibodyFACS/Biofunctional Antibody, Cytokine antibody
Derivation (species)Mouse
Species ReactivityHuman(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m)
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CYR61 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.