human, Cynomolgus/ Rhesus macaque, rat, mouse Fas ligand (TNF superfamily, member 6)(FASL) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.

Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse Fas ligand (TNF superfamily, member 6) (FASL) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Fas-mediated apoptosis proceeds through the extrinsic pathway via the binding to their respective receptors of ligands, such as FasL, tumor necrosis factor-alpha (TNF-α), lymphotoxin-alpha (LT-α), TNF-like protein-1A (TL1A), and Apo2L/TNF-related apoptosis-inducing ligand (TRAIL). FasL is the ligand for the Fas receptor. TNF-α and LT-α are ligands for the TNF superfamily member 1A (TNFR1), TL1A is a ligand for TNF receptor superfamily member 25 (DR3), and TRAIL is a ligand for the TNF receptor superfamily member 10a (DR4/TRAIL-R1) or tumor necrosis factor receptor superfamily member 10b (DR5/TRAIL-R2). These receptors are members of a subset of the TNF receptor super family known as DRs. Engagement of DRs of their cognate ligands promotes recruitment and activation of the apoptosis-initiating proteases caspase-8 and caspase-10 within membrane receptor complexes. This gene is involved in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus; pancreatic cancer; and pre-eclampsia.

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