human, Cynomolgus/ Rhesus macaque, rat, mouse bone morphogenetic protein receptor, type II (serine/threonine kinase)(BMPR2) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.
Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse bone morphogenetic protein receptor, type II (serine/threonine kinase) (BMPR2) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Bone morphogenetic protein receptor type II or BMPR2 is a serine/threonine receptor kinase. It binds Bone morphogenetic proteins, members of the TGF beta superfamily of ligands, which are involved in paracrine signalling. BMPs are involved in a host of cellular functions including osteogenesis, cell growth and cell differentiation. Signaling in the BMP pathway begins with the binding of a BMP to the type II receptor. This causes the recruitment of a BMP type I receptor, which it phosphorylates. The Type I receptor phosphorylates an R-SMAD a transcriptional regulator.
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Catalog No. | Product Name | Antigen: Species Antibody: Species Reactivity | Size | Price |
GM-Tg-hg-T60213-Ag-1 | bone morphogenetic protein receptor, type II (serine/threonine kinase) (BMPR2) protein | human | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-hg-T60213-Ab-1 | Anti-BMPR2 monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-hg-T60213-Ab-2 | Anti-BMPR2 monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-rg-T60213-Ag-1 | bone morphogenetic protein receptor, type II (serine/threonine kinase) (BMPR2) | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-rg-T60213-Ab-1 | Anti-BMPR2 monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-rg-T60213-Ab-2 | Anti-BMPR2 monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-mg-T60213-Ag-1 | bone morphogenetic protein receptor, type II (serine/threonine kinase) (BMPR2) | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-mg-T60213-Ab-1 | Anti-BMPR2 monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-mg-T60213-Ab-2 | Anti-BMPR2 monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-cynog-T60213-Ag-1 | bone morphogenetic protein receptor, type II (serine/threonine kinase) (BMPR2) | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-cynog-T60213-Ab-1 | Anti-BMPR2 monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-cynog-T60213-Ab-2 | Anti-BMPR2 monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
Shipping Cost: | 760.00 |
Description
Target Information
Target Name | BMPR2 |
Full name | bone morphogenetic protein receptor, type II (serine/threonine kinase) |
Gene ID | 659 |
Gene Name | BMPR2 |
Gene Alias | BMPR-II, BMPR3, BMR2, BRK-3, POVD1, PPH1, T-ALK |
Protein Sub-location | Transmembrane Protein |
Antigen Information
Cat No. | GM-Tg-hg-T60213-Ag-1, GM-Tg-rg-T60213-Ag-1, GM-Tg-mg-T60213-Ag-1, GM-Tg-cynog-T60213-Ag-1 |
Products Name | bone morphogenetic protein receptor, type II (serine/threonine kinase) (BMPR2) protein |
Species | human, Cynomolgus/ Rhesus macaque, rat, mouse |
Isotypes | Recombinant protein |
Expression platform | Mammalian cell |
Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated |
Tag | His |
Product Description | Recombinant human, Cynomolgus/ Rhesus macaque, rat, mouse bone morphogenetic protein receptor, type II (serine/threonine kinase) (BMPR2) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus. |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Antibody Information
Catalog No. | GM-Tg-hg-T60213-Ab-1, GM-Tg-hg-T60213-Ab-2, GM-Tg-rg-T60213-Ab-1, GM-Tg-rg-T60213-Ab-2, GM-Tg-mg-T60213-Ab-1, GM-Tg-mg-T60213-Ab-2, GM-Tg-cynog-T60213-Ab-1, GM-Tg-cynog-T60213-Ab-2 |
Products Name | Anti-BMPR2 monoclonal antibody |
Format | mab |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
Derivation (species) | Mouse |
Species Reactivity | Human(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m) |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-BMPR2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |