human, Cynomolgus/ Rhesus macaque, rat, mouse tumor necrosis factor (ligand) superfamily, member 4(TNFSF4) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.

Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse tumor necrosis factor (ligand) superfamily, member 4 (TNFSF4) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

OX40L is the ligand for OX40 (also known as CD134 or TNFRSF4) and is stably expressed on many antigen-presenting cells such as DC2s (a subtype of dendritic cells), macrophages, and activated B lymphocytes. The OX40 molecule, on the other hand, is present on the surface of activated T lymphocytes (mainly CD4+ T cells), but also on NK cells, NKT cells, and neutrophils. The ligation of OX40-OX40L is a source of survival signal for T cells and enables the development of memory T cells. Signalization through these two molecules also leads to polarization towards Th2 immune response even in the environment with low levels of IL-4 cytokine. OX40L is also present on the surface of many non-immune cells, for example on the endothelial cells and the smooth muscle cells. The surface expression of OX40L is induced by many pro-inflammatory mediators, such as TNF-α, e.g. produced by mast cells, IFN-γ and PGE2 (Prostaglandin E2). OX40L has also been designated CD252 (cluster of differentiation 252). Various single-nucleotide polymorphisms (SNPs) of the OX40L gene have been identified. For some of them association with systemic lupus erythematosus has been reported: No association with occurrence of atherosclerosis has been found.

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