human, Cynomolgus/ Rhesus macaque, rat, mouse tumor necrosis factor (ligand) superfamily, member 10(TNFSF10) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.


Target products collectionGo to TNFSF10/TNFSF10 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse tumor necrosis factor (ligand) superfamily, member 10 (TNFSF10) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

In the field of cell biology, TNF-related apoptosis-inducing ligand (TRAIL), is a protein functioning as a ligand that induces the process of cell death called apoptosis. TRAIL is a cytokine that is produced and secreted by most normal tissue cells. It causes apoptosis primarily in tumor cells, by binding to certain death receptors. TRAIL and its receptors have been used as the targets of several anti-cancer therapeutics since the mid-1990s, such as Mapatumumab. However, as of 2013, these have not shown significant survival benefit. TRAIL has also been implicated as a pathogenic or protective factor in various pulmonary diseases, particularly pulmonary arterial hypertension. TRAIL has also been designated CD253 (cluster of differentiation 253) and TNFSF10 (tumor necrosis factor (ligand) superfamily, member 10).


Order information


* GeneMedi provides NON-PROFIT PRICE to support Academic research. Please click inquiry for product quotation. → Inquiry

Catalog No.Product NameAntigen: Species
Antibody: Species Reactivity		SizePrice
GM-Tg-hg-T46084-Ag-1tumor necrosis factor (ligand) superfamily, member 10 (TNFSF10) proteinhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T46084-Ab-1Anti-TNFSF10 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T46084-Ab-2Anti-TNFSF10 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T46084-Ag-1tumor necrosis factor (ligand) superfamily, member 10 (TNFSF10)rat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T46084-Ab-1Anti-TNFSF10 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T46084-Ab-2Anti-TNFSF10 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T46084-Ag-1tumor necrosis factor (ligand) superfamily, member 10 (TNFSF10)mouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T46084-Ab-1Anti-TNFSF10 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T46084-Ab-2Anti-TNFSF10 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T46084-Ag-1tumor necrosis factor (ligand) superfamily, member 10 (TNFSF10)Cynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T46084-Ab-1Anti-TNFSF10 monoclonal antibodyCynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T46084-Ab-2Anti-TNFSF10 monoclonal antibodyCynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

Description


Target Information

Target NameTNFSF10
Full nametumor necrosis factor (ligand) superfamily, member 10
Gene ID8743
Gene NameTNFSF10
Gene AliasAPO2L, Apo-2L, CD253, TL2, TNLG6A, TRAIL
Protein Sub-locationSecreted Protein/Potential Cytokines

Antigen Information

Cat No.GM-Tg-hg-T46084-Ag-1, GM-Tg-rg-T46084-Ag-1, GM-Tg-mg-T46084-Ag-1, GM-Tg-cynog-T46084-Ag-1
Products Nametumor necrosis factor (ligand) superfamily, member 10 (TNFSF10) protein
Specieshuman, Cynomolgus/ Rhesus macaque, rat, mouse
IsotypesRecombinant protein
Expression platformMammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated
TagHis
Product DescriptionRecombinant human, Cynomolgus/ Rhesus macaque, rat, mouse tumor necrosis factor (ligand) superfamily, member 10 (TNFSF10) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
ApplicationCell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis.
Formulation & ReconstitutionLyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.GM-Tg-hg-T46084-Ab-1, GM-Tg-hg-T46084-Ab-2,
GM-Tg-rg-T46084-Ab-1, GM-Tg-rg-T46084-Ab-2,
GM-Tg-mg-T46084-Ab-1, GM-Tg-mg-T46084-Ab-2,
GM-Tg-cynog-T46084-Ab-1, GM-Tg-cynog-T46084-Ab-2
Products NameAnti-TNFSF10 monoclonal antibody
Formatmab
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
Species ReactivityHuman(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m)
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TNFSF10 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.