human, Cynomolgus/ Rhesus macaque, rat, mouse interleukin 12 receptor, beta 2(IL12RB2) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.
Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse interleukin 12 receptor, beta 2 (IL12RB2) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor. IL12RB2 is its human gene. IL12RB2 orthologs have been identified in all mammals for which complete genome data are available.
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The co-expression of this and IL12Rβ1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. While the IL12Rβ1 subunit is constitutively expressed, the expression of the IL12RB2 gene is up-regulated by interferon gamma. In Th1 cells, IL-12 signaling through the IL12 receptor leads to the phosphorylation of STAT4 and continued Th1 differentiation. The IL12Rβ2 subunit plays an important role in Th1 cell differentiation, since its absence leads to an abortive Th1 differentiation that has dysfunctional production of Th1 effector molecules. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.
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Catalog No. | Product Name | Antigen: Species Antibody: Species Reactivity | Size | Price |
GM-Tg-hg-T43524-Ag-1 | interleukin 12 receptor, beta 2 (IL12RB2) protein | human | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-hg-T43524-Ab-1 | Anti-IL12RB2 monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-hg-T43524-Ab-2 | Anti-IL12RB2 monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-rg-T43524-Ag-1 | interleukin 12 receptor, beta 2 (IL12RB2) | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-rg-T43524-Ab-1 | Anti-IL12RB2 monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-rg-T43524-Ab-2 | Anti-IL12RB2 monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-mg-T43524-Ag-1 | interleukin 12 receptor, beta 2 (IL12RB2) | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-mg-T43524-Ab-1 | Anti-IL12RB2 monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-mg-T43524-Ab-2 | Anti-IL12RB2 monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-cynog-T43524-Ag-1 | interleukin 12 receptor, beta 2 (IL12RB2) | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-cynog-T43524-Ab-1 | Anti-IL12RB2 monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-cynog-T43524-Ab-2 | Anti-IL12RB2 monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
Shipping Cost: | 760.00 |
Description
Target Information
Target Name | IL12RB2 |
Full name | interleukin 12 receptor, beta 2 |
Gene ID | 3595 |
Gene Name | IL12RB2 |
Gene Alias | |
Protein Sub-location | Transmembrane Protein |
Antigen Information
Cat No. | GM-Tg-hg-T43524-Ag-1, GM-Tg-rg-T43524-Ag-1, GM-Tg-mg-T43524-Ag-1, GM-Tg-cynog-T43524-Ag-1 |
Products Name | interleukin 12 receptor, beta 2 (IL12RB2) protein |
Species | human, Cynomolgus/ Rhesus macaque, rat, mouse |
Isotypes | Recombinant protein |
Expression platform | Mammalian cell |
Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated |
Tag | His |
Product Description | Recombinant human, Cynomolgus/ Rhesus macaque, rat, mouse interleukin 12 receptor, beta 2 (IL12RB2) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus. |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis. |
Formulation | Supplied as a 0.2 μM filtered solution of PBS, PH7.4. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Antibody Information
Catalog No. | GM-Tg-hg-T43524-Ab-1, GM-Tg-hg-T43524-Ab-2, GM-Tg-rg-T43524-Ab-1, GM-Tg-rg-T43524-Ab-2, GM-Tg-mg-T43524-Ab-1, GM-Tg-mg-T43524-Ab-2, GM-Tg-cynog-T43524-Ab-1, GM-Tg-cynog-T43524-Ab-2 |
Products Name | Anti-IL12RB2 monoclonal antibody |
Format | mab |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
Derivation (species) | Mouse |
Species Reactivity | Human(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m) |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-IL12RB2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |