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human, Cynomolgus/ Rhesus macaque, rat, mouse erb-b2 receptor tyrosine kinase 2(ERBB2) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.
Go to HER2/ERBB2 products collection >>Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse erb-b2 receptor tyrosine kinase 2 (ERBB2) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Receptor tyrosine-protein kinase erbB-2, also known as CD340 (cluster of differentiation 340), proto-oncogene Neu, Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. ERBB is abbreviated from erythroblastic oncogene B, a gene isolated from avian genome. It is also frequently called HER2 (from human epidermal growth factor receptor 2) or HER2/neu.
HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients.
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| Catalog No. | Product Name | Antigen: Species Antibody: Species Reactivity | Size | Price |
| GM-Tg-hg-T14597-Ag-1 | erb-b2 receptor tyrosine kinase 2 (ERBB2) protein | human | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-hg-T14597-Ab-1 | Anti-ERBB2 monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-hg-T14597-Ab-2 | Anti-ERBB2 monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-rg-T14597-Ag-1 | erb-b2 receptor tyrosine kinase 2 (ERBB2) | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-rg-T14597-Ab-1 | Anti-ERBB2 monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-rg-T14597-Ab-2 | Anti-ERBB2 monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-mg-T14597-Ag-1 | erb-b2 receptor tyrosine kinase 2 (ERBB2) | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-mg-T14597-Ab-1 | Anti-ERBB2 monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-mg-T14597-Ab-2 | Anti-ERBB2 monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-cynog-T14597-Ag-1 | erb-b2 receptor tyrosine kinase 2 (ERBB2) | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-cynog-T14597-Ab-1 | Anti-ERBB2 monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-cynog-T14597-Ab-2 | Anti-ERBB2 monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
| Shipping Cost: | 760.00 | |||
Description
Target Information
| Target Name | ERBB2 |
| Full name | erb-b2 receptor tyrosine kinase 2 |
| Gene ID | 2064 |
| Gene Name | ERBB2 |
| Gene Alias | CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1 |
| Protein Sub-location | Transmembrane Protein |
Antigen Information
| Cat No. | GM-Tg-hg-T14597-Ag-1, GM-Tg-rg-T14597-Ag-1, GM-Tg-mg-T14597-Ag-1, GM-Tg-cynog-T14597-Ag-1 |
| Products Name | erb-b2 receptor tyrosine kinase 2 (ERBB2) protein |
| Species | human, Cynomolgus/ Rhesus macaque, rat, mouse |
| Isotypes | Recombinant protein |
| Expression platform | Mammalian cell |
| Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated |
| Tag | His |
| Product Description | Recombinant human, Cynomolgus/ Rhesus macaque, rat, mouse erb-b2 receptor tyrosine kinase 2 (ERBB2) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus. |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Antibody Information
| Catalog No. | GM-Tg-hg-T14597-Ab-1, GM-Tg-hg-T14597-Ab-2, GM-Tg-rg-T14597-Ab-1, GM-Tg-rg-T14597-Ab-2, GM-Tg-mg-T14597-Ab-1, GM-Tg-mg-T14597-Ab-2, GM-Tg-cynog-T14597-Ab-1, GM-Tg-cynog-T14597-Ab-2 |
| Products Name | Anti-HER2/ERBB2 monoclonal antibody |
| Format | mab |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| Species Reactivity | Human(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m) |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HER2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
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