human, Cynomolgus/ Rhesus macaque, rat, mouse IL-12 p70(IL12A) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.


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Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse IL-12 p70 (IL12A) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Interleukin-12, p70 (IL-12 p70) is a disulfide-linked heterodimeric 70-kDa cytokine composed of a 197 amino acid 35-kDA (p35) subunit and a 306 amino acid 40-kDa (p40) subunit. It is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells in response to antigenic stimulation. IL-12 stimulates growth and function of T cells, production of interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) from T cells and natural killer (NK) cells, and reduces IL-4-mediated suppression of IFN-γ. IL-12 has been reported to be associated with autoimmune and inflammatory conditions. Increased IL-12 plasma levels may also be detected in patients with neurological disorders such as multiple sclerosis.


Order information


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Catalog No.Product NameAntigen: Species
Antibody: Species Reactivity		SizePrice
GM-Tg-hg-T13251-Ag-1IL-12 p70 (IL12A) proteinhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T13251-Ab-1Anti-IL12A monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T13251-Ab-2Anti-IL12A monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T13251-Ag-1IL-12 p70 (IL12A)rat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T13251-Ab-1Anti-IL12A monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T13251-Ab-2Anti-IL12A monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T13251-Ag-1IL-12 p70 (IL12A)mouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T13251-Ab-1Anti-IL12A monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T13251-Ab-2Anti-IL12A monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T13251-Ag-1IL-12 p70 (IL12A)Cynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T13251-Ab-1Anti-IL12A monoclonal antibodyCynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T13251-Ab-2Anti-IL12A monoclonal antibodyCynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

Description


Target Information

Target NameIL12A
Full nameIL-12 p70
Gene ID3592
Gene NameIL12A
Gene AliasCLMF, IL-12A, NFSK, NKSF1, P35
Protein Sub-locationSecreted Protein/Potential Cytokines

Antigen Information

Cat No.GM-Tg-hg-T13251-Ag-1, GM-Tg-rg-T13251-Ag-1, GM-Tg-mg-T13251-Ag-1, GM-Tg-cynog-T13251-Ag-1
Products NameIL-12 p70 (IL12A) protein
Specieshuman, Cynomolgus/ Rhesus macaque, rat, mouse
IsotypesRecombinant protein
Expression platformMammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated
TagHis
Product DescriptionRecombinant human, Cynomolgus/ Rhesus macaque, rat, mouse IL-12 p70 (IL12A) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
ApplicationCell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis.
Formulation & ReconstitutionLyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.GM-Tg-hg-T13251-Ab-1, GM-Tg-hg-T13251-Ab-2,
GM-Tg-rg-T13251-Ab-1, GM-Tg-rg-T13251-Ab-2,
GM-Tg-mg-T13251-Ab-1, GM-Tg-mg-T13251-Ab-2,
GM-Tg-cynog-T13251-Ab-1, GM-Tg-cynog-T13251-Ab-2
Products NameAnti-IL12A monoclonal antibody
Formatmab
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
Species ReactivityHuman(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m)
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IL12A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.