human, Cynomolgus/ Rhesus macaque, rat, mouse insulin-like growth factor binding protein 4(IGFBP4) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.


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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse insulin-like growth factor binding protein 4 (IGFBP4) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Insulin-like growth factor-binding protein 4 is a protein that in humans is encoded by the IGFBP4 gene. This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. IGFBP-4 is a unique protein and it consistently inhibits several cancer cells in vivo and in vitro. Its inhibitory action has been shown in vivo in prostate and colon. It is secreted by all colon cancer cells.


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Catalog No.Product NameAntigen: Species
Antibody: Species Reactivity		SizePrice
GM-Tg-hg-SE0986-Ag-1insulin-like growth factor binding protein 4 (IGFBP4) proteinhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-SE0986-Ab-1Anti-IGFBP4 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-SE0986-Ab-2Anti-IGFBP4 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-SE0986-Ag-1insulin-like growth factor binding protein 4 (IGFBP4)rat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-SE0986-Ab-1Anti-IGFBP4 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-SE0986-Ab-2Anti-IGFBP4 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-SE0986-Ag-1insulin-like growth factor binding protein 4 (IGFBP4)mouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-SE0986-Ab-1Anti-IGFBP4 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-SE0986-Ab-2Anti-IGFBP4 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-SE0986-Ag-1insulin-like growth factor binding protein 4 (IGFBP4)Cynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-SE0986-Ab-1Anti-IGFBP4 monoclonal antibodyCynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-SE0986-Ab-2Anti-IGFBP4 monoclonal antibodyCynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

Description


Target Information

Target NameIGFBP4
Full nameinsulin-like growth factor binding protein 4
Gene ID3487
Gene NameIGFBP4
Gene AliasBP-4, HT29-IGFBP, IBP4, IGFBP-4
Protein Sub-locationSecreted Protein/Potential Cytokines

Antigen Information

Cat No.GM-Tg-hg-SE0986-Ag-1, GM-Tg-rg-SE0986-Ag-1, GM-Tg-mg-SE0986-Ag-1, GM-Tg-cynog-SE0986-Ag-1
Products Nameinsulin-like growth factor binding protein 4 (IGFBP4) protein
Specieshuman, Cynomolgus/ Rhesus macaque, rat, mouse
IsotypesRecombinant protein
Expression platformMammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated
TagHis
Product DescriptionRecombinant human, Cynomolgus/ Rhesus macaque, rat, mouse insulin-like growth factor binding protein 4 (IGFBP4) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
ApplicationCell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis.
Formulation & ReconstitutionLyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.GM-Tg-hg-SE0986-Ab-1, GM-Tg-hg-SE0986-Ab-2,
GM-Tg-rg-SE0986-Ab-1, GM-Tg-rg-SE0986-Ab-2,
GM-Tg-mg-SE0986-Ab-1, GM-Tg-mg-SE0986-Ab-2,
GM-Tg-cynog-SE0986-Ab-1, GM-Tg-cynog-SE0986-Ab-2
Products NameAnti-IGFBP4 monoclonal antibody
Formatmab
Category of antibodyFACS/Biofunctional Antibody, Cytokine antibody
Derivation (species)Mouse
Species ReactivityHuman(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m)
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IGFBP4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.