human, Cynomolgus/ Rhesus macaque, rat, mouse fibroblast growth factor 9 (glia-activating factor)(FGF9) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.
Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse fibroblast growth factor 9 (glia-activating factor) (FGF9) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Glia-activating factor is a protein that in humans is encoded by the FGF9 gene.The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis. This gene is involved in the patterning of sex determination, lung development, and skeletal development..FGF9 has also been shown to play a vital role in male sex development. FGF9’s role in sex determination begins with its expression in the bi-potent gonads for both females and males. Once activated by SOX9, it is responsible for forming a feedforward loop with Sox9, increasing the levels of both genes. It forms a positive feedback loop upregulating SOX9, while simultaneously inactivating the female Wnt4 signaling pathway. The absence of Fgf9 causes an individual, even an individual with X and Y chromosomes, to develop into a female, as it is needed to carry out important masculinizing developmental functions such as the multiplication of Sertoli cells and creation of the testis cords.
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Catalog No. | Product Name | Antigen: Species Antibody: Species Reactivity | Size | Price |
GM-Tg-hg-SE0923-Ag-1 | fibroblast growth factor 9 (glia-activating factor) (FGF9) protein | human | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-hg-SE0923-Ab-1 | Anti-FGF9 monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-hg-SE0923-Ab-2 | Anti-FGF9 monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-rg-SE0923-Ag-1 | fibroblast growth factor 9 (glia-activating factor) (FGF9) | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-rg-SE0923-Ab-1 | Anti-FGF9 monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-rg-SE0923-Ab-2 | Anti-FGF9 monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-mg-SE0923-Ag-1 | fibroblast growth factor 9 (glia-activating factor) (FGF9) | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-mg-SE0923-Ab-1 | Anti-FGF9 monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-mg-SE0923-Ab-2 | Anti-FGF9 monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-cynog-SE0923-Ag-1 | fibroblast growth factor 9 (glia-activating factor) (FGF9) | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-cynog-SE0923-Ab-1 | Anti-FGF9 monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-cynog-SE0923-Ab-2 | Anti-FGF9 monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
Shipping Cost: | 760.00 |
Description
Target Information
Target Name | FGF9 |
Full name | fibroblast growth factor 9 (glia-activating factor) |
Gene ID | 2254 |
Gene Name | FGF9 |
Gene Alias | FGF-9, GAF, HBFG-9, HBGF-9, SYNS3 |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Antigen Information
Cat No. | GM-Tg-hg-SE0923-Ag-1, GM-Tg-rg-SE0923-Ag-1, GM-Tg-mg-SE0923-Ag-1, GM-Tg-cynog-SE0923-Ag-1 |
Products Name | fibroblast growth factor 9 (glia-activating factor) (FGF9) protein |
Species | human, Cynomolgus/ Rhesus macaque, rat, mouse |
Isotypes | Recombinant protein |
Expression platform | Mammalian cell |
Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated |
Tag | His |
Product Description | Recombinant human, Cynomolgus/ Rhesus macaque, rat, mouse fibroblast growth factor 9 (glia-activating factor) (FGF9) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus. |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Antibody Information
Catalog No. | GM-Tg-hg-SE0923-Ab-1, GM-Tg-hg-SE0923-Ab-2, GM-Tg-rg-SE0923-Ab-1, GM-Tg-rg-SE0923-Ab-2, GM-Tg-mg-SE0923-Ab-1, GM-Tg-mg-SE0923-Ab-2, GM-Tg-cynog-SE0923-Ab-1, GM-Tg-cynog-SE0923-Ab-2 |
Products Name | Anti-FGF9 monoclonal antibody |
Format | mab |
Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
Derivation (species) | Mouse |
Species Reactivity | Human(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m) |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-FGF9 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |