human, Cynomolgus/ Rhesus macaque, rat, mouse tumor necrosis factor (ligand) superfamily, member 8(Tnfsf8) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.


Target products collectionGo to TNFSF8/TNFSF8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse tumor necrosis factor (ligand) superfamily, member 8 (Tnfsf8) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.


Order information


* GeneMedi provides NON-PROFIT PRICE to support Academic research. Please click inquiry for product quotation. → Inquiry

Catalog No.Product NameAntigen: Species
Antibody: Species Reactivity		SizePrice
GM-Tg-hg-MP1859-Ag-1tumor necrosis factor (ligand) superfamily, member 8 (Tnfsf8) proteinhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-MP1859-Ab-1Anti-Tnfsf8 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-MP1859-Ab-2Anti-Tnfsf8 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-MP1859-Ag-1tumor necrosis factor (ligand) superfamily, member 8 (Tnfsf8)rat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-MP1859-Ab-1Anti-Tnfsf8 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-MP1859-Ab-2Anti-Tnfsf8 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-MP1859-Ag-1tumor necrosis factor (ligand) superfamily, member 8 (Tnfsf8)mouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-MP1859-Ab-1Anti-Tnfsf8 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-MP1859-Ab-2Anti-Tnfsf8 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-MP1859-Ag-1tumor necrosis factor (ligand) superfamily, member 8 (Tnfsf8)Cynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-MP1859-Ab-1Anti-Tnfsf8 monoclonal antibodyCynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-MP1859-Ab-2Anti-Tnfsf8 monoclonal antibodyCynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

Description


Target Information

Target NameTnfsf8
Full nametumor necrosis factor (ligand) superfamily, member 8
Gene ID944
Gene NameTnfsf8
Gene AliasCD153, CD30L, CD30LG, TNLG3A
Protein Sub-locationTransmembrane Protein

Antigen Information

Cat No.GM-Tg-hg-MP1859-Ag-1, GM-Tg-rg-MP1859-Ag-1, GM-Tg-mg-MP1859-Ag-1, GM-Tg-cynog-MP1859-Ag-1
Products Nametumor necrosis factor (ligand) superfamily, member 8 (Tnfsf8) protein
Specieshuman, Cynomolgus/ Rhesus macaque, rat, mouse
IsotypesRecombinant protein
Expression platformMammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated
TagHis
Product DescriptionRecombinant human, Cynomolgus/ Rhesus macaque, rat, mouse tumor necrosis factor (ligand) superfamily, member 8 (Tnfsf8) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
ApplicationCell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis.
Formulation & ReconstitutionLyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.GM-Tg-hg-MP1859-Ab-1, GM-Tg-hg-MP1859-Ab-2,
GM-Tg-rg-MP1859-Ab-1, GM-Tg-rg-MP1859-Ab-2,
GM-Tg-mg-MP1859-Ab-1, GM-Tg-mg-MP1859-Ab-2,
GM-Tg-cynog-MP1859-Ab-1, GM-Tg-cynog-MP1859-Ab-2
Products NameAnti-TNFSF8 monoclonal antibody
Formatmab
Category of antibodyFACS/Biofunctional Antibody, Cytokine antibody
Derivation (species)Mouse
Species ReactivityHuman(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m)
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TNFSF8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.