human, Cynomolgus/ Rhesus macaque, rat, mouse sprouty homolog 2 (Drosophila)(SPRY2) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.


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Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse sprouty homolog 2 (Drosophila) (SPRY2) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Sprouty homolog 2 (Drosophila), also known as SPRY2, is a protein which in humans is encoded by the SPRY2 gene. This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.


Order information


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Catalog No.Product NameAntigen: Species
Antibody: Species Reactivity		SizePrice
GM-Tg-hg-MP1709-Ag-1sprouty homolog 2 (Drosophila) (SPRY2) proteinhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-MP1709-Ab-1Anti-SPRY2 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-MP1709-Ab-2Anti-SPRY2 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-MP1709-Ag-1sprouty homolog 2 (Drosophila) (SPRY2)rat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-MP1709-Ab-1Anti-SPRY2 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-MP1709-Ab-2Anti-SPRY2 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-MP1709-Ag-1sprouty homolog 2 (Drosophila) (SPRY2)mouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-MP1709-Ab-1Anti-SPRY2 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-MP1709-Ab-2Anti-SPRY2 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-MP1709-Ag-1sprouty homolog 2 (Drosophila) (SPRY2)Cynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-MP1709-Ab-1Anti-SPRY2 monoclonal antibodyCynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-MP1709-Ab-2Anti-SPRY2 monoclonal antibodyCynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

Description


Target Information

Target NameSPRY2
Full namesprouty homolog 2 (Drosophila)
Gene ID10253
Gene NameSPRY2
Gene AliasIGAN3, hSPRY2
Protein Sub-locationTransmembrane Protein

Antigen Information

Cat No.GM-Tg-hg-MP1709-Ag-1, GM-Tg-rg-MP1709-Ag-1, GM-Tg-mg-MP1709-Ag-1, GM-Tg-cynog-MP1709-Ag-1
Products Namesprouty homolog 2 (Drosophila) (SPRY2) protein
Specieshuman, Cynomolgus/ Rhesus macaque, rat, mouse
IsotypesRecombinant protein
Expression platformMammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated
TagHis
Product DescriptionRecombinant human, Cynomolgus/ Rhesus macaque, rat, mouse sprouty homolog 2 (Drosophila) (SPRY2) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
ApplicationCell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis.
Formulation & ReconstitutionLyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.GM-Tg-hg-MP1709-Ab-1, GM-Tg-hg-MP1709-Ab-2,
GM-Tg-rg-MP1709-Ab-1, GM-Tg-rg-MP1709-Ab-2,
GM-Tg-mg-MP1709-Ab-1, GM-Tg-mg-MP1709-Ab-2,
GM-Tg-cynog-MP1709-Ab-1, GM-Tg-cynog-MP1709-Ab-2
Products NameAnti-SPRY2 monoclonal antibody
Formatmab
Category of antibodyFACS/Biofunctional Antibody, Cytokine antibody
Derivation (species)Mouse
Species ReactivityHuman(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m)
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SPRY2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.