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human, Cynomolgus/ Rhesus macaque, rat, mouse GDNF family receptor alpha 1(GFRA1) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.
Go to GFRA1/GFRA1 products collection >>Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse GDNF family receptor alpha 1 (GFRA1) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
GDNF family receptor alpha-1 (GFRα1), also known as the GDNF receptor, is a protein that in humans is encoded by the GFRA1 gene.
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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| Catalog No. | Product Name | Antigen: Species Antibody: Species Reactivity | Size | Price |
| GM-Tg-hg-MP0478-Ag-1 | GDNF family receptor alpha 1 (GFRA1) protein | human | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-hg-MP0478-Ab-1 | Anti-GFRA1 monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-hg-MP0478-Ab-2 | Anti-GFRA1 monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-rg-MP0478-Ag-1 | GDNF family receptor alpha 1 (GFRA1) | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-rg-MP0478-Ab-1 | Anti-GFRA1 monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-rg-MP0478-Ab-2 | Anti-GFRA1 monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-mg-MP0478-Ag-1 | GDNF family receptor alpha 1 (GFRA1) | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-mg-MP0478-Ab-1 | Anti-GFRA1 monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-mg-MP0478-Ab-2 | Anti-GFRA1 monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-cynog-MP0478-Ag-1 | GDNF family receptor alpha 1 (GFRA1) | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-cynog-MP0478-Ab-1 | Anti-GFRA1 monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
| GM-Tg-cynog-MP0478-Ab-2 | Anti-GFRA1 monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
| Shipping Cost: | 760.00 | |||
Description
Target Information
| Target Name | GFRA1 |
| Full name | GDNF family receptor alpha 1 |
| Gene ID | 2674 |
| Gene Name | GFRA1 |
| Gene Alias | GDNFR, GDNFRA, GFR-ALPHA-1, RET1L, RETL1, TRNR1 |
| Protein Sub-location | Transmembrane Protein |
Antigen Information
| Cat No. | GM-Tg-hg-MP0478-Ag-1, GM-Tg-rg-MP0478-Ag-1, GM-Tg-mg-MP0478-Ag-1, GM-Tg-cynog-MP0478-Ag-1 |
| Products Name | GDNF family receptor alpha 1 (GFRA1) protein |
| Species | human, Cynomolgus/ Rhesus macaque, rat, mouse |
| Isotypes | Recombinant protein |
| Expression platform | Mammalian cell |
| Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated |
| Tag | His |
| Product Description | Recombinant human, Cynomolgus/ Rhesus macaque, rat, mouse GDNF family receptor alpha 1 (GFRA1) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus. |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Antibody Information
| Catalog No. | GM-Tg-hg-MP0478-Ab-1, GM-Tg-hg-MP0478-Ab-2, GM-Tg-rg-MP0478-Ab-1, GM-Tg-rg-MP0478-Ab-2, GM-Tg-mg-MP0478-Ab-1, GM-Tg-mg-MP0478-Ab-2, GM-Tg-cynog-MP0478-Ab-1, GM-Tg-cynog-MP0478-Ab-2 |
| Products Name | Anti-GFRA1 monoclonal antibody |
| Format | mab |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| Species Reactivity | Human(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m) |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GFRA1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
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