human, Cynomolgus/ Rhesus macaque, rat, mouse SMAD family member 1(SMAD1) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.
Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse SMAD family member 1 (SMAD1) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Mothers against decapentaplegic homolog 1 also known as SMAD family member 1 or SMAD1 is a protein that in humans is encoded by the SMAD1 gene.
SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
SMAD1 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase.
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Catalog No. | Product Name | Antigen: Species Antibody: Species Reactivity | Size | Price |
GM-Tg-hg-IP2743-Ag-1 | SMAD family member 1 (SMAD1) protein | human | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-hg-IP2743-Ab-1 | Anti-SMAD1 monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-hg-IP2743-Ab-2 | Anti-SMAD1 monoclonal antibody | human | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-rg-IP2743-Ag-1 | SMAD family member 1 (SMAD1) | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-rg-IP2743-Ab-1 | Anti-SMAD1 monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-rg-IP2743-Ab-2 | Anti-SMAD1 monoclonal antibody | rat | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-mg-IP2743-Ag-1 | SMAD family member 1 (SMAD1) | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-mg-IP2743-Ab-1 | Anti-SMAD1 monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-mg-IP2743-Ab-2 | Anti-SMAD1 monoclonal antibody | mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-cynog-IP2743-Ag-1 | SMAD family member 1 (SMAD1) | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-cynog-IP2743-Ab-1 | Anti-SMAD1 monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-cynog-IP2743-Ab-2 | Anti-SMAD1 monoclonal antibody | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
Shipping Cost: | 760.00 |
Description
Target Information
Target Name | SMAD1 |
Full name | SMAD family member 1 |
Gene ID | 4086 |
Gene Name | SMAD1 |
Gene Alias | BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1 |
Protein Sub-location | Introcelluar Protein |
Antigen Information
Cat No. | GM-Tg-hg-IP2743-Ag-1, GM-Tg-rg-IP2743-Ag-1, GM-Tg-mg-IP2743-Ag-1, GM-Tg-cynog-IP2743-Ag-1 |
Products Name | SMAD family member 1 (SMAD1) protein |
Species | human, Cynomolgus/ Rhesus macaque, rat, mouse |
Isotypes | Recombinant protein |
Expression platform | Mammalian cell |
Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated |
Tag | His |
Product Description | Recombinant human, Cynomolgus/ Rhesus macaque, rat, mouse SMAD family member 1 (SMAD1) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus. |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Antibody Information
Catalog No. | GM-Tg-hg-IP2743-Ab-1, GM-Tg-hg-IP2743-Ab-2, GM-Tg-rg-IP2743-Ab-1, GM-Tg-rg-IP2743-Ab-2, GM-Tg-mg-IP2743-Ab-1, GM-Tg-mg-IP2743-Ab-2, GM-Tg-cynog-IP2743-Ab-1, GM-Tg-cynog-IP2743-Ab-2 |
Products Name | Anti-SMAD1 monoclonal antibody |
Format | mab |
Category of antibody | Cytokine antibody |
Derivation (species) | Mouse |
Species Reactivity | Human(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m) |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-SMAD1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |