Diagnostic Phospho-tau217 (p-tau217) antigen for Neuropathy p-tau217 detection in ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA),immunonephelometry and POCT.

Alzheimer Disease(AD) Recent publications and meeting presentations bolster the evidence that upticks in p-tau181, p-tau217, and p-tau231 occur soon after Aβ begins to accumulate in the brain. That’s years before neurofibrillary tangles can be detected by PET, and decades before symptoms. Researchers predict these markers, which also distinguish AD from other forms of dementia, will lead to more robust tests than those based on Aβ, because of their larger dynamic range—phosphorylated fragments of tau climb by as much as 10-fold in the blood as AD progresses, whereas the Aβ42/40 ratio falls by about 15 percent at most.

Genemedi produces core diagnostic ingredients for test of Neuropathy and related syndrome.

GeneMedi offers paired diagnostics grade Phospho-tau217 (p-tau217) antibodies (monoclonal antibody,mab)and Phospho-tau217 (p-tau217) antigens for Neuropathy rapid test kit of Phospho-tau217 (p-tau217) testing in ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA),immunonephelometry and POCT.

All the antibodies and antigens for Neuropathy test are suitable for in functional ELISA, and other immunoassays in dignostics.The antibodies can act as a capture antibody and detection antibody.The antigens can be used for antibodies rapid test of Neuropathy.

Order information

With the COVID9 outbreak in the world, many flights have been cancelled. In order for the customer to receive the goods properly, we use the FedEx Customized Freight (FCF) of Fedex which demands a higher fee. If the delivery fee is more expensive in your area, we will contact you by mail.

Catalog No.	Size	Price(In USD)	Qty (Quantity)	Sum(In USD)
GMP-p-tau217-antigen	Size:1mg	1823.2
GMP-p-tau217-antigen	Size:10mg	14813.5
GMP-p-tau217-antigen	Size:100mg	75749.6
GMP-p-tau217-antigen	≥100mg	Inquiry
			Shipping Cost:	760.00
			Total:

Description

Cat No.	GMP-p-tau217-antigen
Product Name	Phospho-tau217 (p-tau217) antigen
Expression platform	Synthetic
Bioactivity validation	Phospho-tau217 (p-tau217) Antibody Binding, Immunogen in positive control, Sandwich ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT
Products description	Phospho-tau217 (p-tau217) antigen is synthesized
Purity	Purity: ≥95% (SDS-PAGE)
Application	positive control, ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

GeneMedi's p-tau217/Tau and p-tau181/Tau antibody pairs show good performance in serological diagnosis of Alzheimer's Disease (AD) blood test

Established biomarkers for Alzheimer’s disease, including beta-amyloid (Aβ) and tau. Compared with CSF-based measurements, blood-based biomarkers have the potential to be deployed widely due to the lower costs and less invasiveness. Decreased beta-amyloid 42/beta-amyloid 40(Aβ42/Aβ40) ratio and increased p-tau217 and p-tau181 were associated with subsequent Alzheimer’s disease diagnosis¹. Both p-tau217 and p-tau181 had an excellent diagnostic performance for differentiating patients with Alzheimer’s disease syndromes from other neurodegenerative disorders. Besides, P-tau217 was a stronger indicator than p-tau181².

GeneMedi's p-tau217/Tau and p-tau181/Tau antibody pairs show good performance in diagnosis of Alzheimer's Disease blood test. Recently, Eli Lilly's P-tau217 Serological Test also showed high accuracy in diagnosis of Alzheimer's Disease, which was published in JAMA.

Cat No.	Antibody/Antigen Name
GMP-p-tau217-Ab	Anti-Phospho-tau217 (p-tau217) mouse monoclonal antibody (mAb)
GMP-p-tau217-antigen	Phospho-tau217 (p-tau217) antigen (positive control)
GMP-p-tau181-Ab	Anti-Phospho-tau181 (p-tau181) mouse monoclonal antibody (mAb)
GMP-p-tau181-antigen	Phospho-tau181 (p-tau181) antigen (positive control)
GMP-Tau-Ab	Anti-tau proteins (tau) mouse monoclonal antibody (mAb)

Reference

[1] Adam M. Brickman. Plasma p-tau181, p-tau217, and other blood-based Alzheimer’s disease biomarkers in a multi-ethnic, community study. Alzheimer’s Dement. 2021;17:1353–1364.
[2] Elisabeth H Thijssen. Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer’s disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study. Lancet Neurol 2021; 20: 739–52.