Diagnostic recombinant neurofilament light chain (NFL) antigens (recombinant neurofilament light chain (NFL) ) protein) for Neuropathy NFL detection in positive control, ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.

Neurofilaments are cytoskeletal components of neurons that are particularly abundant in axons. Their functions include provision of structural support and maintaining size, shape, and caliber of the axons (1). Neurofilaments belong to the intermediate filaments family, and the triplet comprises three subunits; neurofilament light chain (NF-L), neurofilament medium (NF-M) and neurofilament heavy (NF-H). The nomenclature-light (~68 kDa), -medium (~145 kDa),- and heavy (~200 kDa) refers to the molecular weight of the filaments (2, 3). Following axonal damage in the central nervous system (CNS), neurofilament proteins released into cerebrospinal fluid (CSF) provide an indication of axonal damage and neuronal death. The most extensively subtype studied in this context is NF-L. Given that neurofilaments are found in the cytoplasm of neurons, all diseases that lead to neuronal and axonal damage can increase the CSF-levels of these proteins. In animal studies, NF-L levels have been used as a marker of axonal damage for decades . In humans, neurofilaments were used as markers of neuronal damage in amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD).

Genemedi produces core diagnostic ingredients for test of Neuropathy and related syndrome. GeneMedi offers paired diagnostics grade neurofilament light chain (NFL) antibodies (monoclonal antibody, mab) and neurofilament light chain (NFL) antigens for Neuropathy rapid test kit of neurofilament light chain (NFL) testing in positive control, ELISA test,Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.

All the antibodies and antigens for Neuropathy test are suitable for in functional ELISA, and other immunoassays in dignostics. The antibodies can act as a capture antibody and detection antibody. The antigens can be used for antibodies rapid test of Neuropathy.

Order information

Catalog No.	Size	Price(In USD)	Qty (Quantity)	Sum(In USD)
GMP-NFL-Ag	Size:1mg	3090
GMP-NFL-Ag	Size:10mg	21890
GMP-NFL-Ag	Size:100mg	148000
GMP-NFL-Ag	≥100mg	Inquiry
			Shipping Cost:	760.00
			Total:

Description

Cat No.	GMP-NFL-Ag
Product Name	Recombinant neurofilament light chain (NFL, His Tag)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	neurofilament light chain (NFL) Antibody Binding, Immunogen in Sandwich ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT
Tag	His
Products description	Recombinant neurofilament light chain (NFL, His Tag) is produced by E.coli expression system with a 6His tag.
Specics	NA
Purity	Purity: ≥95% (SDS-PAGE)
Application	positive control,ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.