Anti-TNFA/ TNF/ DIF-alpha monoclonal antibody

Anti-TNFA/ TNF/ DIF-alpha antibody for FACS & in-vivo assay

Target products collectionGo to TNF/TNF products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T20178-Ab-1/ GM-Tg-hg-T20178-Ab-2Anti-Human TNF monoclonal antibodyHuman
GM-Tg-rg-T20178-Ab-1/ GM-Tg-rg-T20178-Ab-2Anti-Rat TNF monoclonal antibodyRat
GM-Tg-mg-T20178-Ab-1/ GM-Tg-mg-T20178-Ab-2Anti-Mouse TNF monoclonal antibodyMouse
GM-Tg-cynog-T20178-Ab-1/ GM-Tg-cynog-T20178-Ab-2Anti-Cynomolgus/ Rhesus macaque TNF monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T20178-Ab-1/ GM-Tg-felg-T20178-Ab-2Anti-Feline TNF monoclonal antibodyFeline
GM-Tg-cang-T20178-Ab-1/ GM-Tg-cang-T20178-Ab-2Anti-Canine TNF monoclonal antibodyCanine
GM-Tg-bovg-T20178-Ab-1/ GM-Tg-bovg-T20178-Ab-2Anti-Bovine TNF monoclonal antibodyBovine
GM-Tg-equg-T20178-Ab-1/ GM-Tg-equg-T20178-Ab-2Anti-Equine TNF monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T20178-Ab-1/ GM-Tg-hg-T20178-Ab-2; GM-Tg-rg-T20178-Ab-1/ GM-Tg-rg-T20178-Ab-2;
GM-Tg-mg-T20178-Ab-1/ GM-Tg-mg-T20178-Ab-2; GM-Tg-cynog-T20178-Ab-1/ GM-Tg-cynog-T20178-Ab-2;
GM-Tg-felg-T20178-Ab-1/ GM-Tg-felg-T20178-Ab-2; GM-Tg-cang-T20178-Ab-1/ GM-Tg-cang-T20178-Ab-2;
GM-Tg-bovg-T20178-Ab-1/ GM-Tg-bovg-T20178-Ab-2; GM-Tg-equg-T20178-Ab-1/ GM-Tg-equg-T20178-Ab-2
Products NameAnti-TNF monoclonal antibody
Formatmab
Target NameTNF
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TNF benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-478Pre-Made Remtolumab biosimilar, Bispecific Dual Variable Domain IG: Anti-IL17A/IL17;TNFA/TNF therapeutic antibody
    BiosimilarGMP-Bios-INN-846Pre-Made Etanercept Biosimilar, Fusion Protein targeting TNF fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting DIF/TNFSF2/TNLG1F
    BiosimilarGMP-Bios-ab-445Pre-Made Placulumab biosimilar, Single Domain Variable Fragment (VL + Fc), Anti-TNFA/TNF Antibody: Anti-DIF/TNFSF2/TNLG1F therapeutic antibody
    BiosimilarGMP-Bios-ab-249Pre-Made Golimumab biosimilar, Whole mAb, Anti-TNFA/TNF Antibody: Anti-DIF/TNFSF2/TNLG1F therapeutic antibody
    BiosimilarGMP-Bios-INN-887Pre-Made Lenercept Biosimilar, Fusion Protein targeting TNF fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting DIF/TNFSF2/TNLG1F
    BiosimilarGMP-Bios-INN-935Pre-Made Onercept Biosimilar, Recombinant Protein targeting TNF: Recombinant therapeutic protein targeting DIF/TNFSF2/TNLG1F
    BiosimilarGMP-Bios-INN-927Pre-Made Nerelimomab Biosimilar, Whole Mab, Anti-Tnf Antibody: Anti-DIF/TNFSF2/TNLG1F therapeutic antibody
    BiosimilarGMP-Bios-INN-721Pre-Made Afelimomab Biosimilar, Fab Fusion, Anti-Tnf Antibody: Anti-DIF/TNFSF2/TNLG1F therapeutic antibody
    BiosimilarGMP-Bios-ab-310Pre-Made Licaminlimab biosimilar, scFv, Anti-TNFA/TNF Antibody: Anti-DIF/TNFSF2/TNLG1F therapeutic antibody
    BiosimilarGMP-Bios-ab-009Pre-Made Adalimumab biosimilar, Whole mAb, Anti-TNFA/TNF Antibody: Anti-DIF/TNFSF2/TNLG1F therapeutic antibody
    BiosimilarGMP-Bios-INN-718Pre-Made Adalimumab Beta Biosimilar, Whole Mab, Anti-Tnf Antibody: Anti-DIF/TNFSF2/TNLG1F therapeutic antibody
    BiosimilarGMP-Bios-INN-1036Pre-Made Tulinercept Biosimilar, Fusion Protein targeting TNF fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting DIF/TNFSF2/TNLG1F
    BiosimilarGMP-Bios-ab-274Pre-Made Infliximab biosimilar, Whole mAb, Anti-TNFA/TNF Antibody: Anti-DIF/TNFSF2/TNLG1F therapeutic antibody
    BiosimilarGMP-Bios-ab-419Pre-Made Ozoralizumab biosimilar, Bispecific Single Domains (VH-VH'-VH), Anti-TNFA/TNF;ALB Antibody: Anti-DIF/TNF-alpha/TNFSF2/TNLG1F;FDAHT/HSA/PRO0883/PRO0903/PRO1341 therapeutic antibody
    BiosimilarGMP-Bios-ab-100Pre-Made Certolizumab biosimilar, Fab, Anti-TNFA/TNF Antibody: Anti-DIF/TNFSF2/TNLG1F therapeutic antibody
    BiosimilarGMP-Bios-INN-938Pre-Made Opinercept Biosimilar, Fusion Protein targeting TNF fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting DIF/TNFSF2/TNLG1F
    Target AntigenProducts DevelopingMulti-species TNFA/ TNF/ DIF-alpha VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T20178-Ag-1Tumor necrosis factor (TNF) protein
    ORF Viral VectorvGMAD000017human TNF Adenovirus particle
    ORF Viral VectorpGMAD000017human TNF Adenovirus plasmid
    ORF Viral VectorpGMAP000307Human TNF Adenovirus plasmid
    ORF Viral VectorvGMAD000416human TNF Adenovirus particle
    ORF Viral VectorpGMAD000416human TNF Adenovirus plasmid
    ORF Viral VectorvGMAP000307Human TNF Adenovirus particle
    ORF Viral VectorpGMLV000125mouse Tnf Lentivirus plasmid
    ORF Viral VectorvGMLV000125mouse Tnf Lentivirus particle


    Target information

    Target IDGM-T20178
    Target NameTNF
    Gene ID7124,21926,24835,715467,403922,493755,280943,100033834
    Gene Symbol and SynonymscTNF,DIF,RATTNF,TNF,TNF-a,TNF-alpha,TNFA,TNFalpha,Tnfsf1a,TNFSF2,TNLG1F
    Uniprot AccessionP01375,P16599,P48094,P51742,P19101,Q06599,P29553
    Uniprot Entry NameTNFA_HUMAN,TNFA_MACMU,TNFA_RAT,TNFA_FELCA,TNFA_CANLF,TNFA_BOVIN,TNFA_HORSE
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Diagnostics Biomarker, Immuno-oncology Target, INN Index, Cytokine Target
    DiseaseOvary Cancer, toluene diisocyanate asthma, Giant Cell Arteritis, Polymyalgia Rheumatica, Chronic Kidney Disease, Dent disease, Hodgkin's disease, Kidney transplant rejection, pancreatic cancer, Chronic Glomerulonephritis, Asthma
    Gene EnsemblENSG00000232810
    Target ClassificationCheckpoint-Immuno Oncology

    The target: TNF, gene name: TNF, also named as DIF-alpha, TNFA, TNFSF2, TNLG1F, TNF. This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Aug 2020].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.