Products & Information Collection of New variant SARS-COV-2 (2019nCOV) -Omicron variant aka B.1.1.529 lineage

The world is in midst of the COVID-19 pandemic. The first known confirmed B.1.1.529 infection was from a specimen collected on 9 November 2021. This variant has a large number of mutations, some of which are concerning. Preliminary evidence suggests an increased risk of reinfection with this variant, as compared to other VOCs. Below is the mutations in the spike:

Figure. Amino acid changes in the spike region of the Omicron variant aka B.1.1.529 lineage genomes¹. Note: In our product, N211I→Δ211.

Spike Mutation in SARS-COV-2 (2019nCOV) Omicron variant aka B.1.1.529 lineage	Spike-S1 Subunit N Terminal	A67V
		Δ69-70
		T95I
		G142D
		Δ143-145
		Δ211-212
		ins214EPE
	Spike-RBD	G339D	Important residues mutation Important residues mutation
		S371L
		S373P
		S375F
		K417N
		N440K
		G446S
		S477N
		T478K
		E484A
		Q493R
		G496S
		Q498R
		N501Y
		Y505H
	Spike-S1 Subunit	T547K
		D614G	A popular mutation in different new SARS-CoV-2 lineage
		H655Y
		N679K
		P681H
	Spike-S1 Subunit	N764K
		D796Y
		N856K
		Q954H
		N969K
		L981F

Table. Amino acid changes in the spike region of the Omicron variant aka B.1.1.529 lineage genomes.

GeneMedi pseudotype virus (pseudovirus) of SARS-COV-2 (2019nCOV) Omicron variant aka B.1.1.529 lineage

Taking responsibility to help accelerate the COVID-19 vaccine and therapeutic antibody discovery and development, GeneMedi had developed the pseudotype virus (pseudovirus) of SARS-COV-2 (2019nCOV) Omicron variant aka B.1.1.529 lineage, which will meet the evaluation of the efficacy of COVID19 vaccines and therapeutic antibodies.

Cat No.	Pseudotyped virus of SARS-CoV-2 Spike Mutation Variants	Order
GM-2019nCoV-PSV39	Spike RBD mutation of SARS-CoV-2(2019nCoV) Pseudotyped virus (Omicron variant aka B.1.1.529) production and Pseudovirus Based Neutralization Assay
GM-2019nCoV-PSV40	Spike whole mutant SARS-CoV-2(2019nCoV)Omicron variant aka B.1.1.529 Pseudotyped virus production and Pseudovirus Based Neutralization Assay

SARS-COV-2 (2019nCOV) Coronavirus Mpro (Coronavirus 3CLpro, 3C-Like protein) & High-throughput screening (HTS) assay for efficacy evaluation and development of antiviral compounds

Coronavirus Mpro (Coronavirus 3CLpro, 3C-Like protein) is a target protein of antiviral compounds, which are valid for all SARS-COV-2 (2019nCOV) lineage, including Omicron variant aka B.1.1.529 lineage. The latest research shows that Pfizer’s paxlovid is effective to SARS-COV-2 (2019nCOV) -Omicron variant aka B.1.1.529 lineage, based on the inhibition of Coronavirus Mpro (Coronavirus 3CLpro, 3C-Like protein). Thus, GeneMedi provides SARS-COV-2 (2019nCOV) Coronavirus Mpro (Coronavirus 3CLpro, 3C-Like protein) & High-throughput screening (HTS) assay for efficacy evaluation and development of antiviral compounds

Cat No.	Antigen Name of 2019-nCoV(SARS-CoV-2)	Source (Expression Host)	Order
GMP-V-2019nCoV-Mpro001	Recombinant 2019nCoV antigen-coronavirus Main Proteinase (Mpro, 3CLpro, His Tag)	E.coli

SARS-COV-2 (2019nCOV) Omicron variant aka B.1.1.529 lineage neutralizing antibody

GeneMedi has quickly screened these three neutralizing antibodies, which are valid for all SARS-COV-2 (2019nCOV) lineage, including Omicron variant aka B.1.1.529 lineage. They could be used as Benchmark Antibody, assist in neutralizing antibody discovery and development.

Cat No.	Neutralizing antibody Name	Isotypes	Order
GMP-V-2019nCoV-SnAb006	Anti-2019-nCoV Spike (Spike RBD domain) human monoclonal neutralizing antibody (IgG1)	Mammalian (human cell)
GMP-V-2019nCoV-SnAb007	Anti-2019-nCoV Spike (Spike RBD domain) human monoclonal neutralizing antibody (IgG1)	Mammalian (human cell)
GMP-V-2019nCoV-SnAb008	Anti-2019-nCoV Spike (Spike RBD domain) human monoclonal neutralizing antibody (IgG1)	Mammalian (human cell)

SARS-COV-2 (2019nCOV) -Omicron variant aka B.1.1.529 lineage of Spike protein & ACE2 competition binding assay for efficacy evaluation of COVID-19 diagnostic, vaccines and therapeutic antibodies

GeneMedi has quickly designed the Spike Protein RBD, Spike S-trimer Protein and Nucleocapsid protein (NP) for COVID-19 SARS-COV-2 (2019nCOV) Omicron variant aka B.1.1.529 lineage to help accelerate the COVID-19 diagnostic, vaccine and therapeutic antibody discovery and development.

Cat No.	Antigen Name of 2019-nCoV(SARS-CoV-2)	Source (Expression Host)	Order
GMP-V-2019nCoV-Smu-027	Recombinant 2019-nCoV(SARS-CoV-2) Spike Protein RBD mutant (Omicron variant aka B.1.1.529)	Mammalian (human cell)
GMP-V-2019nCoV-S-trimer-004	Recombinant 2019-nCoV(SARS-CoV-2) Spike S-trimer Protein (Omicron variant aka B.1.1.529 lineage) with furin cleavage site mutation & T4 fibritin trimerization motif	Mammalian (human cell)
GMP-V-2019nCoV-N003	Recombinant 2019-nCoV(SARS-CoV-2) Omicron variant aka B.1.1.529 Nucleocapsid Protein (N protein,N-His tag)	E.coli
GMP-H-ACE2001	Recombinant human solubale ACE2 protein (soluble hACE2,extracellular hACE2,C-His)	Mammalian (human cell)
GMP-H-ACE2002	Recombinant human solubale ACE2 protein (soluble hACE2,extracellular hACE2,C-FC)	Mammalian (human cell)

GeneMedi codon-optimized spike mammalian expression vector for SARS-COV-2 (2019nCOV) -Omicron variant aka B.1.1.529 lineage

GeneMedi has quickly designed the mammalian expression codon-optimized spike mutation/deletion variant vectors for COVID-19 SARS-COV-2 (2019nCOV) Omicron variant aka B.1.1.529 lineage to help accelerate the COVID-19 vaccine and therapeutic antibody discovery and development.

Cat No.	Gene & Vector description of 2019 nCoV	Vector	Tag	Codon Optimized	Order
GMV-V-2019nCoV-192	pGM-Spike RBD mutation of SARS-CoV-2(2019nCoV) Omicron variant aka B.1.1.529	pcDNA3.1(+)	No tag	Codon Optimized for mamamlian
GMV-V-2019nCoV-193	Ad-Spike RBD mutation of SARS-CoV-2(2019nCoV) Omicron variant aka B.1.1.529	Pre-made adenovirus	C-3FLAG	Codon Optimized for mamamlian
GMV-V-2019nCoV-194	pGMLV-Spike RBD mutation of SARS-CoV-2(2019nCoV) Omicron variant aka B.1.1.529	Lentiviral vector	C-3FLAG	Codon Optimized for mamamlian
GMV-V-2019nCoV-195	pGM-Spike (S1+S2) whole mutation variant of SARS-CoV-2(2019nCoV) Omicron variant aka B.1.1.529	pcDNA3.1(+)	No tag	Codon Optimized for mamamlian
GMV-V-2019nCoV-196	Ad-Spike (S1+S2) whole mutation variant of SARS-CoV-2(2019nCoV) Omicron variant aka B.1.1.529	Pre-made adenovirus	C-3FLAG	Codon Optimized for mamamlian
GMV-V-2019nCoV-197	pGMLV-Spike (S1+S2) whole mutation variant of SARS-CoV-2(2019nCoV) Omicron variant aka B.1.1.529	Lentiviral vector	C-3FLAG	Codon Optimized for mamamlian

Reference

1.https://covdb.stanford.edu/page/mutation-viewer/#omicron

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