Recombinant multi-species SMAD7/ CRCS3/ MADH7 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Target products collectionGo to SMAD7/SMAD7 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SMAD7 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: SMAD7, gene name: SMAD7, also named as CRCS3, MADH7, MADH8. The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].

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Catalog No.Product NameSpeciesSizePrice
GM-Tg-hg-T94695-Ag-1Human SMAD7 proteinHuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T94695-Ag-1Rat SMAD7 proteinRat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T94695-Ag-1Mouse SMAD7 proteinMouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T94695-Ag-1Cynomolgus/ Rhesus macaque SMAD7 proteinCynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
GM-Tg-felg-T94695-Ag-1Feline SMAD7 proteinFeline1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cang-T94695-Ag-1Canine SMAD7 proteinCanine1mg/10mg/100mg/≥100mgInquiry
GM-Tg-bovg-T94695-Ag-1Bovine SMAD7 proteinBovine1mg/10mg/100mg/≥100mgInquiry
GM-Tg-bovg-T94695-Ag-1Equine SMAD7 proteinEquine1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

For more than 100mg, click here forinquiry.>>


Description

Catalog No.GM-Tg-hg-T94695-Ag, GM-Tg-rg-T94695-Ag, GM-Tg-mg-T94695-Ag, GM-Tg-cynog-T94695-Ag,
GM-Tg-felg-T94695-Ag, GM-Tg-cang-T94695-Ag, GM-Tg-bovg-T94695-Ag, GM-Tg-equg-T94695-Ag-1
Products Name SMAD7 protein
SpeciesHuman, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target NameSMAD7
Protein Sub-locationIntrocelluar Protein
IsotypesRecombinant protein
Expression platform Mammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated.
TagHis
Products descriptionRecombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SMAD7 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
PurityPurity: ≥95% (SDS-PAGE)
ApplicationIn vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & ReconstitutionLyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.