Recombinant multi-species JAK1/ JAK-1/ JAK1AB protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine JAK-1/JAK1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: JAK-1, gene name: JAK1, also named as JAK1AB, JTK3, JAK1. This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2020].

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Catalog No.Product NameSpeciesSizePrice
GM-Tg-hg-T62460-Ag-1Human JAK-1/JAK1 proteinHuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T62460-Ag-1Rat JAK-1/JAK1 proteinRat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T62460-Ag-1Mouse JAK-1/JAK1 proteinMouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T62460-Ag-1Cynomolgus/ Rhesus macaque JAK-1/JAK1 proteinCynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
GM-Tg-felg-T62460-Ag-1Feline JAK-1/JAK1 proteinFeline1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cang-T62460-Ag-1Canine JAK-1/JAK1 proteinCanine1mg/10mg/100mg/≥100mgInquiry
GM-Tg-bovg-T62460-Ag-1Bovine JAK-1/JAK1 proteinBovine1mg/10mg/100mg/≥100mgInquiry
GM-Tg-bovg-T62460-Ag-1Equine JAK-1/JAK1 proteinEquine1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

For more than 100mg, click here forinquiry.>>


Description

Catalog No.GM-Tg-hg-T62460-Ag, GM-Tg-rg-T62460-Ag, GM-Tg-mg-T62460-Ag, GM-Tg-cynog-T62460-Ag,
GM-Tg-felg-T62460-Ag, GM-Tg-cang-T62460-Ag, GM-Tg-bovg-T62460-Ag, GM-Tg-equg-T62460-Ag-1
Products Name JAK-1/JAK1 protein
SpeciesHuman, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target NameJAK-1
Protein Sub-locationIntrocelluar Protein
IsotypesRecombinant protein
Expression platform Mammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated.
TagHis
Products descriptionRecombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine JAK-1/JAK1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
PurityPurity: ≥95% (SDS-PAGE)
ApplicationIn vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & ReconstitutionLyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.