Recombinant multi-species CATB/ CTSB/ APPS protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CTSB protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: CTSB, gene name: CTSB, also named as APPS, CPSB, RECEUP. This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Both Cathepsin B and Cathepsin L are involved in the cleavage of the spike protein from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) upon its entry to the human host cell. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Sep 2020].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T61746-Ag-1	Human CTSB protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T61746-Ag-1	Rat CTSB protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T61746-Ag-1	Mouse CTSB protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T61746-Ag-1	Cynomolgus/ Rhesus macaque CTSB protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T61746-Ag-1	Feline CTSB protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T61746-Ag-1	Canine CTSB protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T61746-Ag-1	Bovine CTSB protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T61746-Ag-1	Equine CTSB protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T61746-Ag, GM-Tg-rg-T61746-Ag, GM-Tg-mg-T61746-Ag, GM-Tg-cynog-T61746-Ag, GM-Tg-felg-T61746-Ag, GM-Tg-cang-T61746-Ag, GM-Tg-bovg-T61746-Ag, GM-Tg-equg-T61746-Ag-1
Products Name	CTSB protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	CTSB
Protein Sub-location	Secreted Protein/Potential Cytokines
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CTSB protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.