Recombinant multi-species KDM6B/ JMJD3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Target products collectionGo to KDM6B/KDM6B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine KDM6B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: KDM6B, gene name: KDM6B, also named as JMJD3. The protein encoded by this gene is a lysine-specific demethylase that specifically demethylates di- or tri-methylated lysine 27 of histone H3 (H3K27me2 or H3K27me3). H3K27 trimethylation is a repressive epigenetic mark controlling chromatin organization and gene silencing. This protein can also demethylate non-histone proteins such as retinoblastoma protein. Through its demethylation actvity this gene influences cellular differentiation and development, tumorigenesis, inflammatory diseases, and neurodegenerative diseases. This protein has two classical nuclear localization signals at its N-terminus. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017].

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Catalog No.Product NameSpeciesSizePrice
GM-Tg-hg-T56057-Ag-1Human KDM6B proteinHuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T56057-Ag-1Rat KDM6B proteinRat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T56057-Ag-1Mouse KDM6B proteinMouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T56057-Ag-1Cynomolgus/ Rhesus macaque KDM6B proteinCynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
GM-Tg-felg-T56057-Ag-1Feline KDM6B proteinFeline1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cang-T56057-Ag-1Canine KDM6B proteinCanine1mg/10mg/100mg/≥100mgInquiry
GM-Tg-bovg-T56057-Ag-1Bovine KDM6B proteinBovine1mg/10mg/100mg/≥100mgInquiry
GM-Tg-bovg-T56057-Ag-1Equine KDM6B proteinEquine1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

For more than 100mg, click here forinquiry.>>


Description

Catalog No.GM-Tg-hg-T56057-Ag, GM-Tg-rg-T56057-Ag, GM-Tg-mg-T56057-Ag, GM-Tg-cynog-T56057-Ag,
GM-Tg-felg-T56057-Ag, GM-Tg-cang-T56057-Ag, GM-Tg-bovg-T56057-Ag, GM-Tg-equg-T56057-Ag-1
Products Name KDM6B protein
SpeciesHuman, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target NameKDM6B
Protein Sub-locationIntrocelluar Protein
IsotypesRecombinant protein
Expression platform Mammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated.
TagHis
Products descriptionRecombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine KDM6B protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
PurityPurity: ≥95% (SDS-PAGE)
ApplicationIn vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & ReconstitutionLyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.