Recombinant multi-species RAF1/ c-RAF/ CMD1NN protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine c-RAF/RAF1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The target: c-RAF, gene name: RAF1, also named as CMD1NN, CRAF, NS5, Raf-1, c-Raf. This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008].
Order information
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Catalog No. | Product Name | Species | Size | Price |
GM-Tg-hg-T23673-Ag-1 | Human c-RAF/RAF1 protein | Human | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-rg-T23673-Ag-1 | Rat c-RAF/RAF1 protein | Rat | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-mg-T23673-Ag-1 | Mouse c-RAF/RAF1 protein | Mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-cynog-T23673-Ag-1 | Cynomolgus/ Rhesus macaque c-RAF/RAF1 protein | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-felg-T23673-Ag-1 | Feline c-RAF/RAF1 protein | Feline | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-cang-T23673-Ag-1 | Canine c-RAF/RAF1 protein | Canine | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-bovg-T23673-Ag-1 | Bovine c-RAF/RAF1 protein | Bovine | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-bovg-T23673-Ag-1 | Equine c-RAF/RAF1 protein | Equine | 1mg/10mg/100mg/≥100mg | Inquiry |
Shipping Cost: | 760.00 |
Description
Catalog No. | GM-Tg-hg-T23673-Ag, GM-Tg-rg-T23673-Ag, GM-Tg-mg-T23673-Ag, GM-Tg-cynog-T23673-Ag, GM-Tg-felg-T23673-Ag, GM-Tg-cang-T23673-Ag, GM-Tg-bovg-T23673-Ag, GM-Tg-equg-T23673-Ag-1 |
Products Name | c-RAF/RAF1 protein |
Species | Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine |
Target Name | c-RAF |
Protein Sub-location | Introcelluar Protein |
Isotypes | Recombinant protein |
Expression platform | Mammalian cell |
Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated. |
Tag | His |
Products description | Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine c-RAF/RAF1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Supplied as a 0.2 μM filtered solution of PBS, PH7.4. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
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