Recombinant multi-species RAF1/ c-RAF/ CMD1NN protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine c-RAF/RAF1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: c-RAF, gene name: RAF1, also named as CMD1NN, CRAF, NS5, Raf-1, c-Raf. This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008].

Order information

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T23673-Ag-1	Human c-RAF/RAF1 protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T23673-Ag-1	Rat c-RAF/RAF1 protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T23673-Ag-1	Mouse c-RAF/RAF1 protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T23673-Ag-1	Cynomolgus/ Rhesus macaque c-RAF/RAF1 protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T23673-Ag-1	Feline c-RAF/RAF1 protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T23673-Ag-1	Canine c-RAF/RAF1 protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T23673-Ag-1	Bovine c-RAF/RAF1 protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T23673-Ag-1	Equine c-RAF/RAF1 protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T23673-Ag, GM-Tg-rg-T23673-Ag, GM-Tg-mg-T23673-Ag, GM-Tg-cynog-T23673-Ag, GM-Tg-felg-T23673-Ag, GM-Tg-cang-T23673-Ag, GM-Tg-bovg-T23673-Ag, GM-Tg-equg-T23673-Ag-1
Products Name	c-RAF/RAF1 protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	c-RAF
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine c-RAF/RAF1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.