Recombinant multi-species FYV1/ PIP5K3/ PIKFYVE protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PIP5K3/PIKFYVE protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: PIP5K3, gene name: PIKFYVE, also named as CFD, FAB1, HEL37, PIP5K, PIP5K3, ZFYVE29. Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. The protein plays a key role in cell entry of ebola virus and SARS-CoV-2 by endocytosis Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. [provided by RefSeq, Jul 2021].

Order information

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T02469-Ag-1	Human PIP5K3/PIKFYVE protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T02469-Ag-1	Rat PIP5K3/PIKFYVE protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T02469-Ag-1	Mouse PIP5K3/PIKFYVE protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T02469-Ag-1	Cynomolgus/ Rhesus macaque PIP5K3/PIKFYVE protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T02469-Ag-1	Feline PIP5K3/PIKFYVE protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T02469-Ag-1	Canine PIP5K3/PIKFYVE protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T02469-Ag-1	Bovine PIP5K3/PIKFYVE protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T02469-Ag-1	Equine PIP5K3/PIKFYVE protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T02469-Ag, GM-Tg-rg-T02469-Ag, GM-Tg-mg-T02469-Ag, GM-Tg-cynog-T02469-Ag, GM-Tg-felg-T02469-Ag, GM-Tg-cang-T02469-Ag, GM-Tg-bovg-T02469-Ag, GM-Tg-equg-T02469-Ag-1
Products Name	PIP5K3/PIKFYVE protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	PIP5K3
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PIP5K3/PIKFYVE protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.