Recombinant multi-species SEPP1/ SELENOP/ SELP protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SELENOP protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The target: SELENOP, gene name: SELENOP, also named as SELP, SEPP, SEPP1, SeP. This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in human), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. The use of alternative polyadenylation sites, one located in between the two SECIS elements, results in two populations of mRNAs containing either both (predominant) or just the upstream SECIS element (PMID:27881738). Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Oct 2018].
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Catalog No. | Product Name | Species | Size | Price |
GM-Tg-hg-SE0464-Ag-1 | Human SELENOP protein | Human | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-rg-SE0464-Ag-1 | Rat SELENOP protein | Rat | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-mg-SE0464-Ag-1 | Mouse SELENOP protein | Mouse | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-cynog-SE0464-Ag-1 | Cynomolgus/ Rhesus macaque SELENOP protein | Cynomolgus/ Rhesus macaque | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-felg-SE0464-Ag-1 | Feline SELENOP protein | Feline | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-cang-SE0464-Ag-1 | Canine SELENOP protein | Canine | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-bovg-SE0464-Ag-1 | Bovine SELENOP protein | Bovine | 1mg/10mg/100mg/≥100mg | Inquiry |
GM-Tg-bovg-SE0464-Ag-1 | Equine SELENOP protein | Equine | 1mg/10mg/100mg/≥100mg | Inquiry |
Shipping Cost: | 760.00 |
Description
Catalog No. | GM-Tg-hg-SE0464-Ag, GM-Tg-rg-SE0464-Ag, GM-Tg-mg-SE0464-Ag, GM-Tg-cynog-SE0464-Ag, GM-Tg-felg-SE0464-Ag, GM-Tg-cang-SE0464-Ag, GM-Tg-bovg-SE0464-Ag, GM-Tg-equg-SE0464-Ag-1 |
Products Name | SELENOP protein |
Species | Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine |
Target Name | SELENOP |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Isotypes | Recombinant protein |
Expression platform | Mammalian cell |
Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated. |
Tag | His |
Products description | Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SELENOP protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Supplied as a 0.2 μM filtered solution of PBS, PH7.4. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
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