Recombinant multi-species SEPP1/ SELENOP/ SELP protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SELENOP protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: SELENOP, gene name: SELENOP, also named as SELP, SEPP, SEPP1, SeP. This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in human), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. The use of alternative polyadenylation sites, one located in between the two SECIS elements, results in two populations of mRNAs containing either both (predominant) or just the upstream SECIS element (PMID:27881738). Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Oct 2018].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-SE0464-Ag-1	Human SELENOP protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-SE0464-Ag-1	Rat SELENOP protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-SE0464-Ag-1	Mouse SELENOP protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-SE0464-Ag-1	Cynomolgus/ Rhesus macaque SELENOP protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-SE0464-Ag-1	Feline SELENOP protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-SE0464-Ag-1	Canine SELENOP protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-SE0464-Ag-1	Bovine SELENOP protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-SE0464-Ag-1	Equine SELENOP protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-SE0464-Ag, GM-Tg-rg-SE0464-Ag, GM-Tg-mg-SE0464-Ag, GM-Tg-cynog-SE0464-Ag, GM-Tg-felg-SE0464-Ag, GM-Tg-cang-SE0464-Ag, GM-Tg-bovg-SE0464-Ag, GM-Tg-equg-SE0464-Ag-1
Products Name	SELENOP protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	SELENOP
Protein Sub-location	Secreted Protein/Potential Cytokines
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SELENOP protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.