Recombinant multi-species HMDH/ HMGCR/ LDLCQ3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Target products collectionGo to HMGCR/HMGCR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HMGCR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: HMGCR, gene name: HMGCR, also named as LDLCQ3. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].

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Catalog No.Product NameSpeciesSizePrice
GM-Tg-hg-IP0005-Ag-1Human HMGCR proteinHuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-IP0005-Ag-1Rat HMGCR proteinRat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-IP0005-Ag-1Mouse HMGCR proteinMouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-IP0005-Ag-1Cynomolgus/ Rhesus macaque HMGCR proteinCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-felg-IP0005-Ag-1Feline HMGCR proteinFeline1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cang-IP0005-Ag-1Canine HMGCR proteinCanine1mg/10mg/100mg/≥100mgInquiry
GM-Tg-bovg-IP0005-Ag-1Bovine HMGCR proteinBovine1mg/10mg/100mg/≥100mgInquiry
GM-Tg-bovg-IP0005-Ag-1Equine HMGCR proteinEquine1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00



Description

Catalog No.GM-Tg-hg-IP0005-Ag, GM-Tg-rg-IP0005-Ag, GM-Tg-mg-IP0005-Ag, GM-Tg-cynog-IP0005-Ag,
GM-Tg-felg-IP0005-Ag, GM-Tg-cang-IP0005-Ag, GM-Tg-bovg-IP0005-Ag, GM-Tg-equg-IP0005-Ag-1
Products Name HMGCR protein
SpeciesHuman, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target NameHMGCR
Protein Sub-locationIntrocelluar Protein
IsotypesRecombinant protein
Expression platform Mammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated.
TagHis
Products descriptionRecombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HMGCR protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
PurityPurity: ≥95% (SDS-PAGE)
ApplicationIn vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
FormulationSupplied as a 0.2 μM filtered solution of PBS, PH7.4.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.