Spike HV 69-70 Deletion mutant (ΔH69/ΔV70) SARS-CoV-2(2019nCoV) Pseudotyped virus production and Pseudovirus Based Neutralization Assay

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Catalot Number	Size (T,Test, formalized in 96 well, one test per well)	Price(In USD)	Qty (Quantity)	Sum(In USD)
GM-2019nCoV-PSV17-2	100T	3840
GM-2019nCoV-PSV17-2	200T	5440
GM-2019nCoV-PSV17-2	1000T	21760
GM-2019nCoV-PSV17-2	5000T	87040
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SARS-CoV-2 spike-HV 69-70 Deletion mutation(ΔH69/ΔV70)

Background Reading: Information and products collection of SARS-COV-2 (2019nCOV) UK B.1.1.7 lineage Information and products collection of spike-HV 69-70 Deletion mutation(ΔH69/ΔV70)

The world is in midst of the COVID-19 pandemic caused by SARS-CoV-2 (2019nCoV) infection. The Spike protein (S-protein) of SARS-CoV-2 (2019nCoV) mediates receptor (ACE2) binding and cell entry and is the dominant target of the immune system. Most mutations and deletions of SARS-CoV-2 occur in the coronavirus spike protein.

A deletion H69/V70 in Spike was present in over 3,000 sequences worldwide (2.5% of the available data), and largely in Europe from where most of the sequences in GISAID are derived.

The structural impact of the double deletion was predicted by homology modelling of the spike NTD possessing H69/V70 using SWISS-MODEL. The H69/V70 deletion was predicted to alter the conformation of a protruding loop comprising residues 69-76, with the loop being predicted to be predicted to be pulled in the NTD.

Recently a novel SARS-COV-2 (2019nCOV) lineage, the B.1.1.7 lineage, with serials of site mutation, shows stronger infection ability in the UK. In SARS-COV-2 B.1.1.7 lineage, most mutations and deletions occur in the coronavirus spike protein. These deletions also include SARS-CoV-2 spike-HV 69-70 Deletion mutation(ΔH69/ΔV70).

GeneMedi pseudotype virus (pseudovirus) of SARS-COV-2 (2019nCOV) spike-HV 69-70 Deletion mutation(ΔH69/ΔV70)

GeneMedi codon-optimized spike mammalian expression vector for SARS-COV-2 (2019nCOV) spike-HV 69-70 Deletion mutation(ΔH69/ΔV70)