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Spike N501Y mutant SARS-CoV-2(2019nCoV) Pseudotyped virus production and Pseudovirus Based Neutralization Assay
Cat No.:GM-2019nCoV-PSV16
PSV validated Data Poster Download
Order information
| Catalot Number | Size (T,Test, formalized in 96 well, one test per well) |
Price(In USD) | Qty (Quantity) | Sum(In USD) |
|---|---|---|---|---|
| GM-2019nCoV-PSV16-2 | 100T | 3840 | ||
| GM-2019nCoV-PSV16-2 | 200T | 5440 | ||
| GM-2019nCoV-PSV16-2 | 1000T | 21760 | ||
| GM-2019nCoV-PSV16-2 | 5000T | 87040 | ||
| For larger scale | Click for inquiry. | Click for inquiry. | ||
| Shipping Cost: | 960.00 | |||
| Total: | ||||
SARS-CoV-2 spike-N501Y mutation
The world is in midst of the COVID-19 pandemic caused by SARS-CoV-2 (2019nCoV) infection. The Spike protein (S-protein) of SARS-CoV-2 (2019nCoV) mediates receptor (ACE2) binding and cell entry and is the dominant target of the immune system. Most mutations and deletions of SARS-CoV-2 occur in the coronavirus spike protein. Spike position N501, one of the key contact residues in the receptor-binding domain (RBD), and experimental data suggest mutation N501Y can increase ACE2 receptor affinity (Starr et al. 2020). N501Y has also been associated with increased infectivity and virulence in a mouse model (Gu et al. 2020).
Recently a novel SARS-COV-2 (2019nCOV) lineage, the B.1.1.7 lineage, with serials of site mutation, shows stronger infection ability in the UK. In SARS-COV-2 B.1.1.7 lineage, most mutations and deletions occur in the coronavirus spike protein. These mutantions also include SARS-CoV-2 spike- mutation. N501Y mutation is also found in the South Africa 501Y.V2 lineage.
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