Pre-Made Onfekafusp Alfa Biosimilar, Fusion Protein targeting FN/FN1 fused with human TNF (tumor necrosis factor (TNF) superfamily member 2, TNFSF2, TNF-alpha, TNFA) - trimer: Recombinant therapeutic protein targeting CIG/ED-B/FINCZ/GFND/GFND2/LETS/MSF/SMDCFfor drug discovery and mechanism of action (MOA) research

Pre-Made Onfekafusp Alfa Biosimilar, Fusion Protein targeting FN/FN1 fused with human TNF (tumor necrosis factor (TNF) superfamily member 2, TNFSF2, TNF-alpha, TNFA) - trimer: Recombinant therapeutic protein targeting CIG/ED-B/FINCZ/GFND/GFND2/LETS/MSF/SMDCFis a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

ED-B is predominantly expressed during angiogenesis and tumor growth. Onfekafusp Alfa is an immunocytokine consisting of human pro-inflammatory cytokine tumor necrosis factor alpha (TNFalpha) fused to a human single-chain variable fragment (scFv) directed against the extra-domain B (ED-B) of fibronectin (L19), with potential immunopotentiating and antineoplastic activities. L19 moiety of onfekafusp alfa binds to the ED-B domain of fibronectin on tumor cells in the tumor neovasculature. In turn, the TNFalpha moiety may locally induce an immune response against ED-B fibronectin-expressing tumor cells and may specifically decrease the proliferation of ED-B-expressing tumor cells.

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Catalog No.	Package	Price(In USD)	Qty (Quantity)	Sum(In USD)
GMP-Bios-INN-936-1mg	1mg	3090
GMP-Bios-INN-936-10mg	10mg	Inquiry
GMP-Bios-INN-936-100mg	100mg	Inquiry
GMP-Bios-INN-936-xmg	≥100mg	Inquiry
			Shipping Cost:	760.00
			Total:

Description

Products Name (INN Index)	Recombinant therapeutic protein targeting FN/FN1 fused with human TNF (tumor necrosis factor (TNF) superfamily member 2, TNFSF2, TNF-alpha, TNFA) - trimer (Pre-made Onfekafusp Alfa biosimilar, Fusion Protein)
INN Name	Onfekafusp Alfa
Target	FN/FN1
Format	Fusion Protein
Derivation	human
Species Reactivity	human
CH1 Isotype	[scFv - heavy - kappa] - trimer
VD LC	[scFv - heavy - kappa] - trimer
Highest_Clin_Trial (Jan '20)
Est. Status
100% SI Structure
99% SI Structure
95-98% SI Structure
Year Proposed
Year Recommended
Companies	Philogen (Sovicille Italy)
Conditions Approved
Conditions Active
Conditions Discontinued
Development Tech	0