Pre-made Metelimumab benchmark antibody (Whole mAb, anti-TGFB1 therapeutic antibody, Anti-CED/DPD1/IBDIMDE/LAP Antibody) for drug discovery and mechanism of action (MOA) research

Anti-TGFB1 therapeutic antibody (Pre-made Metelimumab biosimilar, Whole mAb) is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Metelimumab (CAT-192) is a human IgG4 monoclonal antibody that neutralizes TGF beta 1 which had been chosen for further development for the treatment of diffuse cutaneous systemic sclerosis, also known as scleroderma.[1] It was dropped from further development in favour of fresolimumab,[2] which was being developed by Genzyme as of 26.[3]

Order information

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Catalog No.	Package	Price(In USD)	Qty (Quantity)	Sum(In USD)
GMP-Bios-INN-908-1mg	1mg	3090
GMP-Bios-INN-908-10mg	10mg	Inquiry
GMP-Bios-INN-908-100mg	100mg	Inquiry
GMP-Bios-INN-908-xmg	≥100mg	Inquiry
			Shipping Cost:	760.00
			Total:

Description

Products Name (INN Index)	Pre-Made Metelimumab Biosimilar, Whole Mab, Anti-Tgfb1 Antibody: Anti-CED/DPD1/IBDIMDE/LAP therapeutic antibody
INN Name	Metelimumab
Target	TGFB1
Format	Whole mAb
Derivation	human
Species Reactivity	human
CH1 Isotype	IgG4 - kappa
VD LC	IgG4 - kappa
Highest_Clin_Trial (Jan '20)
Est. Status
100% SI Structure
99% SI Structure
95-98% SI Structure
Year Proposed
Year Recommended
Companies	Genzyme Corp. (Cambridge MA USA) / Cambridge Antibody Technology (Cambridge UK)
Conditions Approved
Conditions Active
Conditions Discontinued
Development Tech	0