Pre-Made Anakinra Biosimilar, Recombinant Protein targeting IL1R1: Recombinant therapeutic protein targeting CD121A/D2S1473/IL-1R-alpha/IL1R/IL1RA/P80 for drug discovery and mechanism of action (MOA) research

Pre-Made Anakinra Biosimilar, Recombinant Protein targeting IL1R1: Recombinant therapeutic protein targeting CD121A/D2S1473/IL-1R-alpha/IL1R/IL1RA/P80 is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Anakinra, sold under the brand name Kineret, is a biopharmaceutical medication used to treat rheumatoid arthritis, cryopyrin-associated periodic syndromes, familial Mediterranean fever, and Still's disease.[3] It is a recombinant and slightly modified version of the human interleukin 1 receptor antagonist protein.[3] It is marketed by Swedish Orphan Biovitrum.[1] Anakinra is administered by subcutaneous injection.[2]

Anakinra is used to treat rheumatoid arthritis, cryopyrin-associated periodic syndromes, familial Mediterranean fever, and Still's disease. Anakinra is a recombinant, non-glycosylated human interleukin-1 receptor antagonist (IL-1Ra). The anakinra has an extra methionine residue at the amino terminus compared to the native human IL-1Ra. Anakinra binds competitively to the Interleukin-1 type I receptor (IL-1RI), thereby inhibiting the action of elevated levels IL-1 which normally can lead to cartilage degradation and bone resorption.

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Catalog No.	Package	Price(In USD)	Qty (Quantity)	Sum(In USD)
GMP-Bios-INN-732-1mg	1mg	3090
GMP-Bios-INN-732-10mg	10mg	Inquiry
GMP-Bios-INN-732-100mg	100mg	Inquiry
GMP-Bios-INN-732-xmg	≥100mg	Inquiry
			Shipping Cost:	760.00
			Total:

Description

Products Name (INN Index)	Pre-Made Anakinra Biosimilar, Recombinant Protein targeting IL1R1: Recombinant therapeutic protein targeting CD121A/D2S1473/IL-1R-alpha/IL1R/IL1RA/P80
INN Name	Anakinra
Target	IL1R1
Format	Recombinant Protein
Derivation	human
Species Reactivity	human
CH1 Isotype	IL1RN (interleukin 1 receptor antagonist, IL1RA, IL-1RN, "interleukin-1 receptor antagonist protein") recombinant, non glycosylated
VD LC	IL1RN (interleukin 1 receptor antagonist, IL1RA, IL-1RN, "interleukin-1 receptor antagonist protein") recombinant, non glycosylated
Highest_Clin_Trial (Jan '20)
Est. Status
100% SI Structure
99% SI Structure
95-98% SI Structure
Year Proposed
Year Recommended
Companies	Amgen (Thousand Oaks CA USA) / BioVitrum (Saint- Petersburg Russia)
Conditions Approved
Conditions Active
Conditions Discontinued
Development Tech	0