Pre-Made Aldesleukin biosimilar, Recombinant Protein: Recombinant therapeutic protein targeting IL2

Recombinant therapeutic protein targeting IL2 (Pre-made Aldesleukin biosimilar, Recombinant Protein) is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Aldesleukin is a recombinant analog of interleukin-2 used to induce an adaptive immune response in the treatment of renal cell carcinoma. Aldesleukin binds to the IL-2 receptor which leads to heterodimerization of the cytoplasmic domains of the IL-2R beta and gamma(c) chains, activation of the tyrosine kinase Jak3, and phosphorylation of tyrosine residues on the IL-2R beta chain. These events led to the creation of an activated receptor complex, to which various cytoplasmic signaling molecules are recruited and become substrates for regulatory enzymes (especially tyrosine kinases) that are associated with the receptor. These events stimulate growth and differentiation of T cells.

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Catalog No.	Package	Price(In USD)	Qty (Quantity)	Sum(In USD)
GMP-Bios-INN-728-1mg	1mg	3090
GMP-Bios-INN-728-10mg	10mg	Inquiry
GMP-Bios-INN-728-100mg	100mg	Inquiry
GMP-Bios-INN-728-xmg	≥100mg	Inquiry
			Shipping Cost:	760.00
			Total:

Description

Products Name (INN Index)	Recombinant therapeutic protein targeting IL2 (Pre-made Aldesleukin biosimilar, Recombinant Protein)
INN Name	Aldesleukin
Target	IL2
Format	Recombinant Protein
Derivation	0
Species Reactivity	human
CH1 Isotype	IL2 (interleukin 2, IL-2) 1-133
VD LC	IL2 (interleukin 2, IL-2) 1-133
Highest_Clin_Trial (Jan '20)
Est. Status
100% SI Structure
99% SI Structure
95-98% SI Structure
Year Proposed
Year Recommended
Companies	Chiron Corporation (Emeryville CA USA)
Conditions Approved
Conditions Active
Conditions Discontinued
Development Tech	0