HIF-1A/HIF1A: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD

It's the GeneMedi's summary page for Target/Biomarker Introduction of HIF-1A/HIF1A. The page also collects GeneMedi's different modalities and formats products for HIF-1A in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the HIF-1A target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Introcelluar Protein.

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]

Target IDGM-IP0067
Target NameHIF-1A
Gene ID3091,15251,29560,704678,480348,101083686,281814,100061166
Gene Symbol and SynonymsbHLHe78,HIF-1-alpha,HIF-1A,HIF-1alpha,HIF1,HIF1-ALPHA,HIF1A,HIF1alpha,MOP1,PASD8
Uniprot AccessionQ16665,O35800,Q9XTA5
Uniprot Entry NameHIF1A_HUMAN,HIF1A_RAT,HIF1A_BOVIN
Protein Sub-locationIntrocelluar Protein
CategoryTherapeutics Target
DiseaseCancer
Gene EnsemblENSG00000100644
Target ClassificationTumor-associated antigen (TAA)


Pre-made anti-HIF-1A inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-HIF-1A monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-HIF-1A mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Antibody NameSpeciesFormatClassified by tagDetail
Anti-HIF-1A/HIF1A monoclonal antibodyHuman, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquinemabTherapeutics Target antibodyDetail



Recombinant multi-species HIF1A/ HIF-1A/ HIF-1-alpha protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HIF-1A/HIF1A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Products NameSpeciesExpression PlatformDetail
HIF-1A/HIF1A proteinHuman, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquineMammalian cellDetail



Pre-made HIF1A viral vector in GM Promise-ORFTM

Cat No.Products nameNM IDSpeciesTypeDetail
pGMLV000495human HIF1A Lentivirus plasmidNM_001530.3HumanLentivirus plasmidDetail
vGMLV000323human HIF1A Lentivirus particleNM_001530.3HumanLentivirus particleDetail
vGMLV000727human HIF1A Lentivirus particleNM_001530.3HumanLentivirus particleDetail
pGMAD000098human HIF1A Adenovirus plasmidNM_001243084.1HumanAdenovirus plasmidDetail
vGMLV000495human HIF1A Lentivirus particleNM_001530.3HumanLentivirus particleDetail
pGMLV000727human HIF1A Lentivirus plasmidNM_001530.3HumanLentivirus plasmidDetail
pGMLV000323human HIF1A Lentivirus plasmidNM_001530.3HumanLentivirus plasmidDetail
vGMAD000098human HIF1A Adenovirus particleNM_001243084.1HumanAdenovirus particleDetail
pGMAD000326rat Hif1a Adenovirus plasmidNM_024359.1RatAdenovirus plasmidDetail
pGMAAV000349Norway rat Hif1a AAV plasmidNM_024359.1Norway RatAAV plasmidDetail
pGMLPm004780mouse Hif1a Lentivirus plasmidNM_010431.2MouseLentivirus plasmidDetail
vGMAD000326rat Hif1a Adenovirus particleNM_024359.1RatAdenovirus particleDetail
vGMAAV000349Norway rat Hif1a AAV particleNM_024359.1Norway RatAAV particleDetail
vGMLPm004780mouse Hif1a Lentivirus particleNM_010431.2MouseLentivirus particleDetail

About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI

If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.






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