HIF-1A/HIF1A: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of HIF-1A/HIF1A. The page also collects GeneMedi's different modalities and formats products for HIF-1A in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the HIF-1A target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Introcelluar Protein.
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]
Target ID | GM-IP0067 |
Target Name | HIF-1A |
Gene ID | 3091,15251,29560,704678,480348,101083686,281814,100061166 |
Gene Symbol and Synonyms | bHLHe78,HIF-1-alpha,HIF-1A,HIF-1alpha,HIF1,HIF1-ALPHA,HIF1A,HIF1alpha,MOP1,PASD8 |
Uniprot Accession | Q16665,O35800,Q9XTA5 |
Uniprot Entry Name | HIF1A_HUMAN,HIF1A_RAT,HIF1A_BOVIN |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | Cancer |
Gene Ensembl | ENSG00000100644 |
Target Classification | Tumor-associated antigen (TAA) |
Pre-made anti-HIF-1A inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-HIF-1A monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-HIF-1A mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Antibody Name | Species | Format | Classified by tag | Detail |
Anti-HIF-1A/HIF1A monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | Therapeutics Target antibody | Detail |
Recombinant multi-species HIF1A/ HIF-1A/ HIF-1-alpha protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HIF-1A/HIF1A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Products Name | Species | Expression Platform | Detail |
HIF-1A/HIF1A protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made HIF1A viral vector in GM Promise-ORFTM
Cat No. | Products name | NM ID | Species | Type | Detail |
pGMLV000495 | human HIF1A Lentivirus plasmid | NM_001530.3 | Human | Lentivirus plasmid | Detail |
vGMLV000323 | human HIF1A Lentivirus particle | NM_001530.3 | Human | Lentivirus particle | Detail |
vGMLV000727 | human HIF1A Lentivirus particle | NM_001530.3 | Human | Lentivirus particle | Detail |
pGMAD000098 | human HIF1A Adenovirus plasmid | NM_001243084.1 | Human | Adenovirus plasmid | Detail |
vGMLV000495 | human HIF1A Lentivirus particle | NM_001530.3 | Human | Lentivirus particle | Detail |
pGMLV000727 | human HIF1A Lentivirus plasmid | NM_001530.3 | Human | Lentivirus plasmid | Detail |
pGMLV000323 | human HIF1A Lentivirus plasmid | NM_001530.3 | Human | Lentivirus plasmid | Detail |
vGMAD000098 | human HIF1A Adenovirus particle | NM_001243084.1 | Human | Adenovirus particle | Detail |
pGMAD000326 | rat Hif1a Adenovirus plasmid | NM_024359.1 | Rat | Adenovirus plasmid | Detail |
pGMAAV000349 | Norway rat Hif1a AAV plasmid | NM_024359.1 | Norway Rat | AAV plasmid | Detail |
pGMLPm004780 | mouse Hif1a Lentivirus plasmid | NM_010431.2 | Mouse | Lentivirus plasmid | Detail |
vGMAD000326 | rat Hif1a Adenovirus particle | NM_024359.1 | Rat | Adenovirus particle | Detail |
vGMAAV000349 | Norway rat Hif1a AAV particle | NM_024359.1 | Norway Rat | AAV particle | Detail |
vGMLPm004780 | mouse Hif1a Lentivirus particle | NM_010431.2 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.