Human HIF1A/bHLHe78/HIF-1-alpha ORF/cDNA clone-Lentivirus particle (NM_001530.3)
Cat. No.: vGMLV000727
Pre-made Human HIF1A/bHLHe78/HIF-1-alpha Lentiviral expression plasmid for HIF1A lentivirus packaging, HIF1A lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.
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Catalog No. | Product Name | lentivirus Grade | lentivirus quantity |
---|---|---|---|
vGMLV000727 | Human HIF1A Lentivirus particle | Pilot Grade | 1.0E+8TU |
5.0E+8TU | |||
1.0E+9TU | |||
Research Grade | 1.0E+8TU | ||
5.0E+8TU | |||
1.0E+9TU | |||
GMP-like Grade | inquiry | ||
GMP Grade | inquiry |
Product Description
Catalog ID | vGMLV000727 |
Gene Name | HIF1A |
Accession Number | NM_001530.3 |
Gene ID | 3091 |
Species | Human |
Product Type | Lentivirus particle (overexpression) |
Insert Length | 2481 bp |
Gene Alias | bHLHe78,HIF-1-alpha,HIF-1A,HIF-1alpha,HIF1,HIF1-ALPHA,MOP1,PASD8 |
Fluorescent Reporter | Null |
Mammalian Cell Selection | Puromyocin |
Fusion Tag | 3xflag (C-Terminal) |
Promoter | CMV |
Resistance | Amplicin |
Reference
Data / case study
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Associated products
Target information
Target ID | GM-IP0067 |
Target Name | HIF-1A |
Gene ID | 3091, 15251, 704678, 29560, 101083686, 480348, 281814, 100061166 |
Gene Symbol and Synonyms | bHLHe78,HIF-1-alpha,HIF-1A,HIF-1alpha,HIF1,HIF1-ALPHA,HIF1A,HIF1alpha,MOP1,PASD8 |
Uniprot Accession | Q16665 |
Uniprot Entry Name | HIF1A_HUMAN |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | Cancer |
Gene Ensembl | ENSG00000100644 |
Target Classification | Tumor-associated antigen (TAA) |
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]
About GMVC
GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.