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Anti-HIF-1A monoclonal antibody
Pre-made anti-HIF-1A monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to HIF-1A/HIF1A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0067-Ab-1/ GM-Tg-hg-IP0067-Ab-2 | Anti-Human HIF-1A/HIF1A monoclonal antibody | Human |
| GM-Tg-rg-IP0067-Ab-1/ GM-Tg-rg-IP0067-Ab-2 | Anti-Rat HIF-1A/HIF1A monoclonal antibody | Rat |
| GM-Tg-mg-IP0067-Ab-1/ GM-Tg-mg-IP0067-Ab-2 | Anti-Mouse HIF-1A/HIF1A monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0067-Ab-1/ GM-Tg-cynog-IP0067-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HIF-1A/HIF1A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0067-Ab-1/ GM-Tg-felg-IP0067-Ab-2 | Anti-Feline HIF-1A/HIF1A monoclonal antibody | Feline |
| GM-Tg-cang-IP0067-Ab-1/ GM-Tg-cang-IP0067-Ab-2 | Anti-Canine HIF-1A/HIF1A monoclonal antibody | Canine |
| GM-Tg-bovg-IP0067-Ab-1/ GM-Tg-bovg-IP0067-Ab-2 | Anti-Bovine HIF-1A/HIF1A monoclonal antibody | Bovine |
| GM-Tg-equg-IP0067-Ab-1/ GM-Tg-equg-IP0067-Ab-2 | Anti-Equine HIF-1A/HIF1A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0067-Ab-1/ GM-Tg-hg-IP0067-Ab-2; GM-Tg-rg-IP0067-Ab-1/ GM-Tg-rg-IP0067-Ab-2; GM-Tg-mg-IP0067-Ab-1/ GM-Tg-mg-IP0067-Ab-2; GM-Tg-cynog-IP0067-Ab-1/ GM-Tg-cynog-IP0067-Ab-2; GM-Tg-felg-IP0067-Ab-1/ GM-Tg-felg-IP0067-Ab-2; GM-Tg-cang-IP0067-Ab-1/ GM-Tg-cang-IP0067-Ab-2; GM-Tg-bovg-IP0067-Ab-1/ GM-Tg-bovg-IP0067-Ab-2; GM-Tg-equg-IP0067-Ab-1/ GM-Tg-equg-IP0067-Ab-2 |
| Products Name | Anti-HIF-1A/HIF1A monoclonal antibody |
| Format | mab |
| Target Name | HIF-1A |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-HIF-1A monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0067-Ag-1 | Recombinant multi-species HIF1A/ HIF-1A/ HIF-1-alpha protein |
| ORF Viral Vector | pGMLV000495 | human HIF1A Lentivirus plasmid |
| ORF Viral Vector | vGMLV000323 | human HIF1A Lentivirus particle |
| ORF Viral Vector | vGMLV000727 | human HIF1A Lentivirus particle |
| ORF Viral Vector | pGMAD000098 | human HIF1A Adenovirus plasmid |
| ORF Viral Vector | vGMLV000495 | human HIF1A Lentivirus particle |
| ORF Viral Vector | pGMLV000727 | human HIF1A Lentivirus plasmid |
| ORF Viral Vector | pGMLV000323 | human HIF1A Lentivirus plasmid |
| ORF Viral Vector | vGMAD000098 | human HIF1A Adenovirus particle |
| ORF Viral Vector | pGMAD000326 | rat Hif1a Adenovirus plasmid |
| ORF Viral Vector | pGMAAV000349 | Norway rat Hif1a AAV plasmid |
| ORF Viral Vector | pGMLPm004780 | mouse Hif1a Lentivirus plasmid |
| ORF Viral Vector | vGMAD000326 | rat Hif1a Adenovirus particle |
| ORF Viral Vector | vGMAAV000349 | Norway rat Hif1a AAV particle |
| ORF Viral Vector | vGMLPm004780 | mouse Hif1a Lentivirus particle |
Target information
| Target ID | GM-IP0067 |
| Target Name | HIF-1A |
| Gene ID | 3091,15251,29560,704678,480348,101083686,281814,100061166 |
| Gene Symbol and Synonyms | bHLHe78,HIF-1-alpha,HIF-1A,HIF-1alpha,HIF1,HIF1-ALPHA,HIF1A,HIF1alpha,MOP1,PASD8 |
| Uniprot Accession | Q16665,O35800,Q9XTA5 |
| Uniprot Entry Name | HIF1A_HUMAN,HIF1A_RAT,HIF1A_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000100644 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: HIF-1A, gene name: HIF1A, also named as HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78. This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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