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Anti-SMAD7 monoclonal antibody
Pre-made anti-SMAD7 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to SMAD7/SMAD7 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T94695-Ab-1/ GM-Tg-hg-T94695-Ab-2 | Anti-Human SMAD7 monoclonal antibody | Human |
| GM-Tg-rg-T94695-Ab-1/ GM-Tg-rg-T94695-Ab-2 | Anti-Rat SMAD7 monoclonal antibody | Rat |
| GM-Tg-mg-T94695-Ab-1/ GM-Tg-mg-T94695-Ab-2 | Anti-Mouse SMAD7 monoclonal antibody | Mouse |
| GM-Tg-cynog-T94695-Ab-1/ GM-Tg-cynog-T94695-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SMAD7 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T94695-Ab-1/ GM-Tg-felg-T94695-Ab-2 | Anti-Feline SMAD7 monoclonal antibody | Feline |
| GM-Tg-cang-T94695-Ab-1/ GM-Tg-cang-T94695-Ab-2 | Anti-Canine SMAD7 monoclonal antibody | Canine |
| GM-Tg-bovg-T94695-Ab-1/ GM-Tg-bovg-T94695-Ab-2 | Anti-Bovine SMAD7 monoclonal antibody | Bovine |
| GM-Tg-equg-T94695-Ab-1/ GM-Tg-equg-T94695-Ab-2 | Anti-Equine SMAD7 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T94695-Ab-1/ GM-Tg-hg-T94695-Ab-2; GM-Tg-rg-T94695-Ab-1/ GM-Tg-rg-T94695-Ab-2; GM-Tg-mg-T94695-Ab-1/ GM-Tg-mg-T94695-Ab-2; GM-Tg-cynog-T94695-Ab-1/ GM-Tg-cynog-T94695-Ab-2; GM-Tg-felg-T94695-Ab-1/ GM-Tg-felg-T94695-Ab-2; GM-Tg-cang-T94695-Ab-1/ GM-Tg-cang-T94695-Ab-2; GM-Tg-bovg-T94695-Ab-1/ GM-Tg-bovg-T94695-Ab-2; GM-Tg-equg-T94695-Ab-1/ GM-Tg-equg-T94695-Ab-2 |
| Products Name | Anti-SMAD7 monoclonal antibody |
| Format | mab |
| Target Name | SMAD7 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-SMAD7 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T94695-Ag-1 | Recombinant multi-species SMAD7/ CRCS3/ MADH7 protein |
| Cytokine | GM-Tg-g-T94695-Ag-1 | SMAD family member 7 (SMAD7) protein |
| ORF Viral Vector | pGMLP001429 | human SMAD7 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001429 | human SMAD7 Lentivirus particle |
| ORF Viral Vector | pGMAAV000122 | mouse Smad7 AAV plasmid |
| ORF Viral Vector | vGMAAV000122 | mouse Smad7 AAV particle |
Target information
| Target ID | GM-T94695 |
| Target Name | SMAD7 |
| Gene ID | 4092,17131,81516,698338,490570,101088277,535916,100033853 |
| Gene Symbol and Synonyms | CRCS3,MADH7,MADH8,SMAD7 |
| Uniprot Accession | O15105,O88406 |
| Uniprot Entry Name | SMAD7_HUMAN,SMAD7_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000101665 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: SMAD7, gene name: SMAD7, also named as CRCS3, MADH7, MADH8. The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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