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Anti-TSLP functional antibody
Anti-TSLP functional antibody for cell culture, ELISA & in-vivo assay
Go to TSLP/TSLP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T85857-Ab-1/ GM-Tg-hg-T85857-Ab-2 | Anti-Human TSLP monoclonal antibody | Human |
| GM-Tg-rg-T85857-Ab-1/ GM-Tg-rg-T85857-Ab-2 | Anti-Rat TSLP monoclonal antibody | Rat |
| GM-Tg-mg-T85857-Ab-1/ GM-Tg-mg-T85857-Ab-2 | Anti-Mouse TSLP monoclonal antibody | Mouse |
| GM-Tg-cynog-T85857-Ab-1/ GM-Tg-cynog-T85857-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TSLP monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T85857-Ab-1/ GM-Tg-felg-T85857-Ab-2 | Anti-Feline TSLP monoclonal antibody | Feline |
| GM-Tg-cang-T85857-Ab-1/ GM-Tg-cang-T85857-Ab-2 | Anti-Canine TSLP monoclonal antibody | Canine |
| GM-Tg-bovg-T85857-Ab-1/ GM-Tg-bovg-T85857-Ab-2 | Anti-Bovine TSLP monoclonal antibody | Bovine |
| GM-Tg-equg-T85857-Ab-1/ GM-Tg-equg-T85857-Ab-2 | Anti-Equine TSLP monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T85857-Ab-1/ GM-Tg-hg-T85857-Ab-2; GM-Tg-rg-T85857-Ab-1/ GM-Tg-rg-T85857-Ab-2; GM-Tg-mg-T85857-Ab-1/ GM-Tg-mg-T85857-Ab-2; GM-Tg-cynog-T85857-Ab-1/ GM-Tg-cynog-T85857-Ab-2; GM-Tg-felg-T85857-Ab-1/ GM-Tg-felg-T85857-Ab-2; GM-Tg-cang-T85857-Ab-1/ GM-Tg-cang-T85857-Ab-2; GM-Tg-bovg-T85857-Ab-1/ GM-Tg-bovg-T85857-Ab-2; GM-Tg-equg-T85857-Ab-1/ GM-Tg-equg-T85857-Ab-2 |
| Products Name | Anti-TSLP monoclonal antibody |
| Format | mab |
| Target Name | TSLP |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TSLP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-567 | Pre-Made Tezepelumab biosimilar, Whole Mab: Anti-TSLP therapeutic antibody |
| Biosimilar | GMP-Bios-ab-662 | Pre-Made Ecleralimab biosimilar, Whole Mab: Anti-TSLP therapeutic antibody |
| Target Antigen | GM-Tg-g-T85857-Ag-1 | Recombinant multi-species TSLP protein |
| ORF Viral Vector | pGMLP004781 | human TSLP Lentivirus plasmid |
| ORF Viral Vector | vGMLP004781 | human TSLP Lentivirus particle |
| ORF Viral Vector | pGMLPm000289 | mouse Tslp Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000289 | mouse Tslp Lentivirus particle |
Target information
| Target ID | GM-T85857 |
| Target Name | TSLP |
| Gene ID | 85480,53603,688621,706194,607671,101085857,617637,100302635 |
| Gene Symbol and Synonyms | TSLP |
| Uniprot Accession | Q969D9 |
| Uniprot Entry Name | TSLP_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, INN Index |
| Disease | N/A |
| Gene Ensembl | ENSG00000145777 |
| Target Classification | N/A |
The target: TSLP, gene name: TSLP, also named as . This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. In addition, the shorter (predominant) isoform is an antimicrobial protein, displaying antibacterial and antifungal activity against B. cereus, E. coli, E. faecalis, S. mitis, S. epidermidis, and C. albicans. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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