- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-PCNA monoclonal antibody
Pre-made anti-PCNA monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PCNA/PCNA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T21782-Ab-1/ GM-Tg-hg-T21782-Ab-2 | Anti-Human PCNA monoclonal antibody | Human |
| GM-Tg-rg-T21782-Ab-1/ GM-Tg-rg-T21782-Ab-2 | Anti-Rat PCNA monoclonal antibody | Rat |
| GM-Tg-mg-T21782-Ab-1/ GM-Tg-mg-T21782-Ab-2 | Anti-Mouse PCNA monoclonal antibody | Mouse |
| GM-Tg-cynog-T21782-Ab-1/ GM-Tg-cynog-T21782-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PCNA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T21782-Ab-1/ GM-Tg-felg-T21782-Ab-2 | Anti-Feline PCNA monoclonal antibody | Feline |
| GM-Tg-cang-T21782-Ab-1/ GM-Tg-cang-T21782-Ab-2 | Anti-Canine PCNA monoclonal antibody | Canine |
| GM-Tg-bovg-T21782-Ab-1/ GM-Tg-bovg-T21782-Ab-2 | Anti-Bovine PCNA monoclonal antibody | Bovine |
| GM-Tg-equg-T21782-Ab-1/ GM-Tg-equg-T21782-Ab-2 | Anti-Equine PCNA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T21782-Ab-1/ GM-Tg-hg-T21782-Ab-2; GM-Tg-rg-T21782-Ab-1/ GM-Tg-rg-T21782-Ab-2; GM-Tg-mg-T21782-Ab-1/ GM-Tg-mg-T21782-Ab-2; GM-Tg-cynog-T21782-Ab-1/ GM-Tg-cynog-T21782-Ab-2; GM-Tg-felg-T21782-Ab-1/ GM-Tg-felg-T21782-Ab-2; GM-Tg-cang-T21782-Ab-1/ GM-Tg-cang-T21782-Ab-2; GM-Tg-bovg-T21782-Ab-1/ GM-Tg-bovg-T21782-Ab-2; GM-Tg-equg-T21782-Ab-1/ GM-Tg-equg-T21782-Ab-2 |
| Products Name | Anti-PCNA monoclonal antibody |
| Format | mab |
| Target Name | PCNA |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-PCNA monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T21782-Ag-1 | Recombinant multi-species PCNA/ ATLD2 protein |
| ORF Viral Vector | vGMLV000281 | human PCNA Lentivirus particle |
| ORF Viral Vector | pGMAP000111 | Human PCNA Adenovirus plasmid |
| ORF Viral Vector | pGMLV000502 | human PCNA Lentivirus plasmid |
| ORF Viral Vector | vGMAP000111 | Human PCNA Adenovirus particle |
| ORF Viral Vector | vGMLV000502 | human PCNA Lentivirus particle |
| ORF Viral Vector | pGMLV000281 | human PCNA Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000423 | mouse Pcna Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000423 | mouse Pcna Lentivirus particle |
Target information
| Target ID | GM-T21782 |
| Target Name | PCNA |
| Gene ID | 5111,18538,25737,718006,477166,101080704,515499,100052065 |
| Gene Symbol and Synonyms | ATLD2,PCNA,Pcna/cyclin,PCNAR |
| Uniprot Accession | P12004,P04961,Q3ZBW4 |
| Uniprot Entry Name | PCNA_HUMAN,PCNA_RAT,PCNA_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Aggressive angiomyxoma (AAM), breast cancer, Proliferation and growth regulation |
| Gene Ensembl | ENSG00000132646 |
| Target Classification | N/A |
The target: PCNA, gene name: PCNA, also named as ATLD2. The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
