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Anti-SOCS1 monoclonal antibody
Pre-made anti-SOCS1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to SOCS1/SOCS1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T06800-Ab-1/ GM-Tg-hg-T06800-Ab-2 | Anti-Human SOCS1 monoclonal antibody | Human |
| GM-Tg-rg-T06800-Ab-1/ GM-Tg-rg-T06800-Ab-2 | Anti-Rat SOCS1 monoclonal antibody | Rat |
| GM-Tg-mg-T06800-Ab-1/ GM-Tg-mg-T06800-Ab-2 | Anti-Mouse SOCS1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T06800-Ab-1/ GM-Tg-cynog-T06800-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SOCS1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T06800-Ab-1/ GM-Tg-felg-T06800-Ab-2 | Anti-Feline SOCS1 monoclonal antibody | Feline |
| GM-Tg-cang-T06800-Ab-1/ GM-Tg-cang-T06800-Ab-2 | Anti-Canine SOCS1 monoclonal antibody | Canine |
| GM-Tg-bovg-T06800-Ab-1/ GM-Tg-bovg-T06800-Ab-2 | Anti-Bovine SOCS1 monoclonal antibody | Bovine |
| GM-Tg-equg-T06800-Ab-1/ GM-Tg-equg-T06800-Ab-2 | Anti-Equine SOCS1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T06800-Ab-1/ GM-Tg-hg-T06800-Ab-2; GM-Tg-rg-T06800-Ab-1/ GM-Tg-rg-T06800-Ab-2; GM-Tg-mg-T06800-Ab-1/ GM-Tg-mg-T06800-Ab-2; GM-Tg-cynog-T06800-Ab-1/ GM-Tg-cynog-T06800-Ab-2; GM-Tg-felg-T06800-Ab-1/ GM-Tg-felg-T06800-Ab-2; GM-Tg-cang-T06800-Ab-1/ GM-Tg-cang-T06800-Ab-2; GM-Tg-bovg-T06800-Ab-1/ GM-Tg-bovg-T06800-Ab-2; GM-Tg-equg-T06800-Ab-1/ GM-Tg-equg-T06800-Ab-2 |
| Products Name | Anti-SOCS1 monoclonal antibody |
| Format | mab |
| Target Name | SOCS1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-SOCS1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T06800-Ag-1 | Recombinant multi-species SOCS1/ CIS1/ CISH1 protein |
| ORF Viral Vector | vGMLP003452 | human SOCS1 Lentivirus particle |
| ORF Viral Vector | pGMLP003452 | human SOCS1 Lentivirus plasmid |
| ORF Viral Vector | pGMLV000858 | human SOCS1 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000858 | human SOCS1 Lentivirus particle |
| ORF Viral Vector | pGMLPm003677 | mouse Socs1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003677 | mouse Socs1 Lentivirus particle |
Target information
| Target ID | GM-T06800 |
| Target Name | SOCS1 |
| Gene ID | 8651,12703,252971,711180,490006,111558242,518795,102148488 |
| Gene Symbol and Synonyms | AISIMD,CIS1,CISH1,Cish7,JAB,SOCS-1,SOCS1,SSI-1,SSI1,TIP-3,TIP3 |
| Uniprot Accession | O15524,Q9QX78 |
| Uniprot Entry Name | SOCS1_HUMAN,SOCS1_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000185338 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: SOCS1, gene name: SOCS1, also named as CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP-3, TIP3. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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