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Anti-I18BP/ IL18BP/ IL18BPa functional antibody
Anti-I18BP/ IL18BP/ IL18BPa functional antibody for cell culture, ELISA & in-vivo assay
Go to IL18BP/IL18BP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1023-Ab-1/ GM-Tg-hg-SE1023-Ab-2 | Anti-Human IL18BP monoclonal antibody | Human |
| GM-Tg-rg-SE1023-Ab-1/ GM-Tg-rg-SE1023-Ab-2 | Anti-Rat IL18BP monoclonal antibody | Rat |
| GM-Tg-mg-SE1023-Ab-1/ GM-Tg-mg-SE1023-Ab-2 | Anti-Mouse IL18BP monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1023-Ab-1/ GM-Tg-cynog-SE1023-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL18BP monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1023-Ab-1/ GM-Tg-felg-SE1023-Ab-2 | Anti-Feline IL18BP monoclonal antibody | Feline |
| GM-Tg-cang-SE1023-Ab-1/ GM-Tg-cang-SE1023-Ab-2 | Anti-Canine IL18BP monoclonal antibody | Canine |
| GM-Tg-bovg-SE1023-Ab-1/ GM-Tg-bovg-SE1023-Ab-2 | Anti-Bovine IL18BP monoclonal antibody | Bovine |
| GM-Tg-equg-SE1023-Ab-1/ GM-Tg-equg-SE1023-Ab-2 | Anti-Equine IL18BP monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1023-Ab-1/ GM-Tg-hg-SE1023-Ab-2; GM-Tg-rg-SE1023-Ab-1/ GM-Tg-rg-SE1023-Ab-2; GM-Tg-mg-SE1023-Ab-1/ GM-Tg-mg-SE1023-Ab-2; GM-Tg-cynog-SE1023-Ab-1/ GM-Tg-cynog-SE1023-Ab-2; GM-Tg-felg-SE1023-Ab-1/ GM-Tg-felg-SE1023-Ab-2; GM-Tg-cang-SE1023-Ab-1/ GM-Tg-cang-SE1023-Ab-2; GM-Tg-bovg-SE1023-Ab-1/ GM-Tg-bovg-SE1023-Ab-2; GM-Tg-equg-SE1023-Ab-1/ GM-Tg-equg-SE1023-Ab-2 |
| Products Name | Anti-IL18BP monoclonal antibody |
| Format | mab |
| Target Name | IL18BP |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL18BP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1023-Ag-1 | Recombinant multi-species I18BP/ IL18BP/ IL18BPa protein |
| Cytokine | GM-Tg-g-SE1023-Ag-1 | interleukin 18 binding protein (IL18BP) protein |
| ORF Viral Vector | pGMLP000015 | human IL18BP Lentivirus plasmid |
| ORF Viral Vector | vGMLP000015 | human IL18BP Lentivirus particle |
| ORF Viral Vector | pGMLPm000547 | mouse Il18bp Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000547 | mouse Il18bp Lentivirus particle |
Target information
| Target ID | GM-SE1023 |
| Target Name | IL18BP |
| Gene ID | 10068,16068,84388,100144607,476818,101096599,617470,100066161 |
| Gene Symbol and Synonyms | FVH,Igifbp,IL-18BP,IL18BP,IL18BPa,MC54L |
| Uniprot Accession | O95998 |
| Uniprot Entry Name | I18BP_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Cytokine Target |
| Disease | Malignant neoplasm of prostate |
| Gene Ensembl | ENSG00000137496 |
| Target Classification | N/A |
The target: IL18BP, gene name: IL18BP, also named as IL18BPa. The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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