VSIR: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD

It's the GeneMedi's summary page for Target/Biomarker Introduction of VSIR. The page also collects GeneMedi's different modalities and formats products for VSIR in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the VSIR target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Transmembrane Protein.

Enables endopeptidase activator activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of macromolecule metabolic process; and regulation of T cell activation. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

Target IDGM-T99704
Target NameVSIR
Gene ID64115,74048,690899,709595,106558705,101096355,783068,102149832
Gene Symbol and Synonyms4632428N05Rik,B7-H5,B7H5,C10orf54,C1H10orf54,C28H10orf54,C4H10orf54,C9H10orf54,C9orf54,CD2H10orf54,DD1alpha,Dies1,GI24,PD-1H,PP2135,SISP1,VISTA,VSIR
Uniprot AccessionQ9H7M9
Uniprot Entry NameVISTA_HUMAN
Protein Sub-locationTransmembrane Protein
CategoryTherapeutics Target, INN Index
DiseaseN/A
Gene EnsemblENSG00000107738
Target ClassificationCheckpoint-Immuno Oncology


Pre-made VSIR-specific INN-index biosimilar (antibody&conjugates)

Anti-VSIR therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).

Cat No.Products Name (INN Index)INN Name Previous Name Target FormatDetail
GMP-Bios-ab-406Pre-Made Onvatilimab biosimilar, Whole mAb, Anti-VSIR Antibody: Anti-B7-H5/B7H5/C10orf54/DD1alpha/Dies1/GI24/PD-1H/PP2135/SISP1/VISTA therapeutic antibodyOnvatilimabVSIRWhole mAbDetail

Click to check more INN-indexed antibody & protein biosimilar



Pre-made anti-VSIR inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-VSIR benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-VSIR mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Antibody NameSpeciesFormatClassified by tagDetail
Anti-VSIR monoclonal antibodyHuman, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquinemabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail



Multi-species VISTA/ VSIR/ B7-H5 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine VSIR VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Products NameSpeciesExpression PlatformDetail
VSIR VLP (virus-like particle)Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquineMammalian cellProducts Developing



Pre-made VSIR viral vector in GM Promise-ORFTM

Cat No.Products nameNM IDSpeciesTypeDetail
pGMLV000879human VSIR Lentivirus plasmidNM_022153.1HumanLentivirus plasmidDetail
vGMLV000880human VSIR Lentivirus particleNM_022153HumanLentivirus particleDetail
pGMLV000880human VSIR Lentivirus plasmidNM_022153HumanLentivirus plasmidDetail
pGMLP004294human VSIR Lentivirus plasmidNM_022153HumanLentivirus plasmidDetail
vGMLP004294human VSIR Lentivirus particleNM_022153HumanLentivirus particleDetail
vGMLV000879human VSIR Lentivirus particleNM_022153.1HumanLentivirus particleDetail
pGMLPm003507mouse Vsir Lentivirus plasmidNM_028732MouseLentivirus plasmidDetail
vGMLPm003507mouse Vsir Lentivirus particleNM_028732MouseLentivirus particleDetail

About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI

If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.






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