Anti-VISTA/ VSIR/ B7-H5 monoclonal antibody

Anti-VISTA/ VSIR/ B7-H5 antibody for FACS & in-vivo assay

Target products collectionGo to VSIR/VSIR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T99704-Ab-1/ GM-Tg-hg-T99704-Ab-2Anti-Human VSIR monoclonal antibodyHuman
GM-Tg-rg-T99704-Ab-1/ GM-Tg-rg-T99704-Ab-2Anti-Rat VSIR monoclonal antibodyRat
GM-Tg-mg-T99704-Ab-1/ GM-Tg-mg-T99704-Ab-2Anti-Mouse VSIR monoclonal antibodyMouse
GM-Tg-cynog-T99704-Ab-1/ GM-Tg-cynog-T99704-Ab-2Anti-Cynomolgus/ Rhesus macaque VSIR monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T99704-Ab-1/ GM-Tg-felg-T99704-Ab-2Anti-Feline VSIR monoclonal antibodyFeline
GM-Tg-cang-T99704-Ab-1/ GM-Tg-cang-T99704-Ab-2Anti-Canine VSIR monoclonal antibodyCanine
GM-Tg-bovg-T99704-Ab-1/ GM-Tg-bovg-T99704-Ab-2Anti-Bovine VSIR monoclonal antibodyBovine
GM-Tg-equg-T99704-Ab-1/ GM-Tg-equg-T99704-Ab-2Anti-Equine VSIR monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T99704-Ab-1/ GM-Tg-hg-T99704-Ab-2; GM-Tg-rg-T99704-Ab-1/ GM-Tg-rg-T99704-Ab-2;
GM-Tg-mg-T99704-Ab-1/ GM-Tg-mg-T99704-Ab-2; GM-Tg-cynog-T99704-Ab-1/ GM-Tg-cynog-T99704-Ab-2;
GM-Tg-felg-T99704-Ab-1/ GM-Tg-felg-T99704-Ab-2; GM-Tg-cang-T99704-Ab-1/ GM-Tg-cang-T99704-Ab-2;
GM-Tg-bovg-T99704-Ab-1/ GM-Tg-bovg-T99704-Ab-2; GM-Tg-equg-T99704-Ab-1/ GM-Tg-equg-T99704-Ab-2
Products NameAnti-VSIR monoclonal antibody
Formatmab
Target NameVSIR
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-VSIR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-406Pre-Made Onvatilimab biosimilar, Whole mAb, Anti-VSIR Antibody: Anti-B7-H5/B7H5/C10orf54/DD1alpha/Dies1/GI24/PD-1H/PP2135/SISP1/VISTA therapeutic antibody
    Target AntigenProducts DevelopingMulti-species VISTA/ VSIR/ B7-H5 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLV000879human VSIR Lentivirus plasmid
    ORF Viral VectorvGMLV000880human VSIR Lentivirus particle
    ORF Viral VectorpGMLV000880human VSIR Lentivirus plasmid
    ORF Viral VectorpGMLP004294human VSIR Lentivirus plasmid
    ORF Viral VectorvGMLP004294human VSIR Lentivirus particle
    ORF Viral VectorvGMLV000879human VSIR Lentivirus particle
    ORF Viral VectorpGMLPm003507mouse Vsir Lentivirus plasmid
    ORF Viral VectorvGMLPm003507mouse Vsir Lentivirus particle


    Target information

    Target IDGM-T99704
    Target NameVSIR
    Gene ID64115,74048,690899,709595,106558705,101096355,783068,102149832
    Gene Symbol and Synonyms4632428N05Rik,B7-H5,B7H5,C10orf54,C1H10orf54,C28H10orf54,C4H10orf54,C9H10orf54,C9orf54,CD2H10orf54,DD1alpha,Dies1,GI24,PD-1H,PP2135,SISP1,VISTA,VSIR
    Uniprot AccessionQ9H7M9
    Uniprot Entry NameVISTA_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, INN Index
    DiseaseN/A
    Gene EnsemblENSG00000107738
    Target ClassificationCheckpoint-Immuno Oncology

    The target: VSIR, gene name: VSIR, also named as B7-H5, B7H5, C10orf54, DD1alpha, GI24, PD-1H, PP2135, SISP1, VISTA. Enables endopeptidase activator activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of macromolecule metabolic process; and regulation of T cell activation. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.