EPCAM: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of EPCAM. The page also collects GeneMedi's different modalities and formats products for EPCAM in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the EPCAM target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Transmembrane Protein.
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]
| Target ID | GM-T47863 |
| Target Name | EPCAM |
| Gene ID | 4072,17075,171577,677680,481360,101081794,514039,100053148 |
| Gene Symbol and Synonyms | Ber-Ep4,BerEp4,CD326,DIAR5,EGP,EGP-2,EGP314,EGP40,Ep-CAM,EPCAM,EpCAM1,ESA,GA733-2,gp40,HNPCC8,KS1/4,KSA,Ly74,LYNCH8,M4S1,MIC18,MK-1,MOC-31,Tacsd1,TACSTD1,TROP1 |
| Uniprot Accession | P16422,O55159,Q1WER1,Q3T0L5 |
| Uniprot Entry Name | EPCAM_HUMAN,EPCAM_MACMU,EPCAM_RAT,EPCAM_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index |
| Disease | Ovary Cancer |
| Gene Ensembl | ENSG00000119888 |
| Target Classification | Checkpoint-Immuno Oncology |
Pre-made EPCAM-specific INN-index biosimilar (antibody&conjugates)
Anti-EPCAM therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Click to check more INN-indexed antibody & protein biosimilar
Pre-made anti-EPCAM inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-EPCAM benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-EPCAM mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
| Antibody Name | Species | Format | Classified by tag | Detail |
| Anti-EPCAM monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Multi-species EPCAM/ DIAR5/ EGP-2 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine EPCAM VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
| Products Name | Species | Expression Platform | Detail |
| EPCAM VLP (virus-like particle) | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Products Developing |
Pre-made EPCAM viral vector in GM Promise-ORFTM
| Cat No. | Products name | NM ID | Species | Type | Detail |
| pGMLV000875 | human EPCAM Lentivirus plasmid | NM_002354.2 | Human | Lentivirus plasmid | Detail |
| vGMAAV000236 | human EPCAM AAV particle | NM_002354 | Human | AAV particle | Detail |
| pGMLV000293 | human EPCAM Lentivirus plasmid | NM_002354.2 | Human | Lentivirus plasmid | Detail |
| vGMLV000293 | human EPCAM Lentivirus particle | NM_002354.2 | Human | Lentivirus particle | Detail |
| vGMLV000875 | human EPCAM Lentivirus particle | NM_002354.2 | Human | Lentivirus particle | Detail |
| pGMAAV000236 | human EPCAM AAV plasmid | NM_002354 | Human | AAV plasmid | Detail |
| pGMAP000558 | Human EPCAM Adenovirus plasmid | BC014785 | Human | Adenovirus plasmid | Detail |
| pGMAAV000214 | human EpCAM AAV plasmid | NM_002354 | Human | AAV plasmid | Detail |
| vGMAP000558 | Human EPCAM Adenovirus particle | BC014785 | Human | Adenovirus particle | Detail |
| vGMAAV000214 | human EpCAM AAV particle | NM_002354 | Human | AAV particle | Detail |
| pGMLPm002282 | mouse Epcam Lentivirus plasmid | NM_008532 | Mouse | Lentivirus plasmid | Detail |
| vGMLPm002282 | mouse Epcam Lentivirus particle | NM_008532 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.
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