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Anti-EPCAM/ DIAR5/ EGP-2 monoclonal antibody
Anti-EPCAM/ DIAR5/ EGP-2 antibody for FACS & in-vivo assay
Go to EPCAM/EPCAM products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T47863-Ab-1/ GM-Tg-hg-T47863-Ab-2 | Anti-Human EPCAM monoclonal antibody | Human |
| GM-Tg-rg-T47863-Ab-1/ GM-Tg-rg-T47863-Ab-2 | Anti-Rat EPCAM monoclonal antibody | Rat |
| GM-Tg-mg-T47863-Ab-1/ GM-Tg-mg-T47863-Ab-2 | Anti-Mouse EPCAM monoclonal antibody | Mouse |
| GM-Tg-cynog-T47863-Ab-1/ GM-Tg-cynog-T47863-Ab-2 | Anti-Cynomolgus/ Rhesus macaque EPCAM monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T47863-Ab-1/ GM-Tg-felg-T47863-Ab-2 | Anti-Feline EPCAM monoclonal antibody | Feline |
| GM-Tg-cang-T47863-Ab-1/ GM-Tg-cang-T47863-Ab-2 | Anti-Canine EPCAM monoclonal antibody | Canine |
| GM-Tg-bovg-T47863-Ab-1/ GM-Tg-bovg-T47863-Ab-2 | Anti-Bovine EPCAM monoclonal antibody | Bovine |
| GM-Tg-equg-T47863-Ab-1/ GM-Tg-equg-T47863-Ab-2 | Anti-Equine EPCAM monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T47863-Ab-1/ GM-Tg-hg-T47863-Ab-2; GM-Tg-rg-T47863-Ab-1/ GM-Tg-rg-T47863-Ab-2; GM-Tg-mg-T47863-Ab-1/ GM-Tg-mg-T47863-Ab-2; GM-Tg-cynog-T47863-Ab-1/ GM-Tg-cynog-T47863-Ab-2; GM-Tg-felg-T47863-Ab-1/ GM-Tg-felg-T47863-Ab-2; GM-Tg-cang-T47863-Ab-1/ GM-Tg-cang-T47863-Ab-2; GM-Tg-bovg-T47863-Ab-1/ GM-Tg-bovg-T47863-Ab-2; GM-Tg-equg-T47863-Ab-1/ GM-Tg-equg-T47863-Ab-2 |
| Products Name | Anti-EPCAM monoclonal antibody |
| Format | mab |
| Target Name | EPCAM |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-EPCAM benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Target information
| Target ID | GM-T47863 |
| Target Name | EPCAM |
| Gene ID | 4072,17075,171577,677680,481360,101081794,514039,100053148 |
| Gene Symbol and Synonyms | Ber-Ep4,BerEp4,CD326,DIAR5,EGP,EGP-2,EGP314,EGP40,Ep-CAM,EPCAM,EpCAM1,ESA,GA733-2,gp40,HNPCC8,KS1/4,KSA,Ly74,LYNCH8,M4S1,MIC18,MK-1,MOC-31,Tacsd1,TACSTD1,TROP1 |
| Uniprot Accession | P16422,O55159,Q1WER1,Q3T0L5 |
| Uniprot Entry Name | EPCAM_HUMAN,EPCAM_MACMU,EPCAM_RAT,EPCAM_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index |
| Disease | Ovary Cancer |
| Gene Ensembl | ENSG00000119888 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: EPCAM, gene name: EPCAM, also named as DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TACSTD1, TROP1. This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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