GJA1: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of GJA1. The page also collects GeneMedi's different modalities and formats products for GJA1 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the GJA1 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Transmembrane Protein.
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations. [provided by RefSeq, May 2014]
Target ID | GM-T44479 |
Target Name | GJA1 |
Gene ID | 2697,14609,24392,714344,403418,101100211,281193,100067229 |
Gene Symbol and Synonyms | AVSD3,CMDR,Cnx43,connexin43,CX43,Cx43alpha1,Cxnk1,EKVP,EKVP3,Gja-1,GJA1,GJAL,HLHS1,HSS,Npm1,ODDD,PPKCA |
Uniprot Accession | P17302,P08050,Q6S9C0,P18246 |
Uniprot Entry Name | CXA1_HUMAN,CXA1_RAT,CXA1_CANLF,CXA1_BOVIN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | Cancer |
Gene Ensembl | ENSG00000152661 |
Target Classification | Tumor-associated antigen (TAA) |
Pre-made anti-GJA1 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-GJA1 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-GJA1 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Antibody Name | Species | Format | Classified by tag | Detail |
Anti-GJA1 monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Multi-species CXA1/ GJA1/ AVSD3 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GJA1 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Products Name | Species | Expression Platform | Detail |
GJA1 VLP (virus-like particle) | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Products Developing |
Pre-made GJA1 viral vector in GM Promise-ORFTM
Cat No. | Products name | NM ID | Species | Type | Detail |
pGMLV000455 | human GJA1 Lentivirus plasmid | NM_000165.4 | Human | Lentivirus plasmid | Detail |
vGMLV000455 | human GJA1 Lentivirus particle | NM_000165.4 | Human | Lentivirus particle | Detail |
pGMAP000184 | Human GJA1 Adenovirus plasmid | BC026329 | Human | Adenovirus plasmid | Detail |
vGMAP000184 | Human GJA1 Adenovirus particle | BC026329 | Human | Adenovirus particle | Detail |
pGMLP001348 | human NM_000165humanNM_000165 Lentivirus plasmid | NM_000165 | Human | Lentivirus plasmid | Detail |
vGMLP001348 | human NM_000165humanNM_000165 Lentivirus particle | NM_000165 | Human | Lentivirus particle | Detail |
pGMLV000150 | mouse Gja1 Lentivirus plasmid | NM_010288 | Mouse | Lentivirus plasmid | Detail |
pGMAD000534 | house mouse Gja1 Adenovirus plasmid | NM_010288 | House Mouse | Adenovirus plasmid | Detail |
vGMLV000150 | mouse Gja1 Lentivirus particle | NM_010288 | Mouse | Lentivirus particle | Detail |
vGMAD000534 | house mouse Gja1 Adenovirus particle | NM_010288 | House Mouse | Adenovirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.