Anti-CXA1/ GJA1/ AVSD3 monoclonal antibody
Anti-CXA1/ GJA1/ AVSD3 antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T44479-Ab-1/ GM-Tg-hg-T44479-Ab-2 | Anti-Human GJA1 monoclonal antibody | Human |
GM-Tg-rg-T44479-Ab-1/ GM-Tg-rg-T44479-Ab-2 | Anti-Rat GJA1 monoclonal antibody | Rat |
GM-Tg-mg-T44479-Ab-1/ GM-Tg-mg-T44479-Ab-2 | Anti-Mouse GJA1 monoclonal antibody | Mouse |
GM-Tg-cynog-T44479-Ab-1/ GM-Tg-cynog-T44479-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GJA1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T44479-Ab-1/ GM-Tg-felg-T44479-Ab-2 | Anti-Feline GJA1 monoclonal antibody | Feline |
GM-Tg-cang-T44479-Ab-1/ GM-Tg-cang-T44479-Ab-2 | Anti-Canine GJA1 monoclonal antibody | Canine |
GM-Tg-bovg-T44479-Ab-1/ GM-Tg-bovg-T44479-Ab-2 | Anti-Bovine GJA1 monoclonal antibody | Bovine |
GM-Tg-equg-T44479-Ab-1/ GM-Tg-equg-T44479-Ab-2 | Anti-Equine GJA1 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T44479-Ab-1/ GM-Tg-hg-T44479-Ab-2; GM-Tg-rg-T44479-Ab-1/ GM-Tg-rg-T44479-Ab-2; GM-Tg-mg-T44479-Ab-1/ GM-Tg-mg-T44479-Ab-2; GM-Tg-cynog-T44479-Ab-1/ GM-Tg-cynog-T44479-Ab-2; GM-Tg-felg-T44479-Ab-1/ GM-Tg-felg-T44479-Ab-2; GM-Tg-cang-T44479-Ab-1/ GM-Tg-cang-T44479-Ab-2; GM-Tg-bovg-T44479-Ab-1/ GM-Tg-bovg-T44479-Ab-2; GM-Tg-equg-T44479-Ab-1/ GM-Tg-equg-T44479-Ab-2 |
Products Name | Anti-GJA1 monoclonal antibody |
Format | mab |
Target Name | GJA1 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-GJA1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species CXA1/ GJA1/ AVSD3 VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | pGMLV000455 | human GJA1 Lentivirus plasmid |
ORF Viral Vector | vGMLV000455 | human GJA1 Lentivirus particle |
ORF Viral Vector | pGMAP000184 | Human GJA1 Adenovirus plasmid |
ORF Viral Vector | vGMAP000184 | Human GJA1 Adenovirus particle |
ORF Viral Vector | pGMLP001348 | human NM_000165humanNM_000165 Lentivirus plasmid |
ORF Viral Vector | vGMLP001348 | human NM_000165humanNM_000165 Lentivirus particle |
ORF Viral Vector | pGMLV000150 | mouse Gja1 Lentivirus plasmid |
ORF Viral Vector | pGMAD000534 | house mouse Gja1 Adenovirus plasmid |
ORF Viral Vector | vGMLV000150 | mouse Gja1 Lentivirus particle |
ORF Viral Vector | vGMAD000534 | house mouse Gja1 Adenovirus particle |
Target information
Target ID | GM-T44479 |
Target Name | GJA1 |
Gene ID | 2697,14609,24392,714344,403418,101100211,281193,100067229 |
Gene Symbol and Synonyms | AVSD3,CMDR,Cnx43,connexin43,CX43,Cx43alpha1,Cxnk1,EKVP,EKVP3,Gja-1,GJA1,GJAL,HLHS1,HSS,Npm1,ODDD,PPKCA |
Uniprot Accession | P17302,P08050,Q6S9C0,P18246 |
Uniprot Entry Name | CXA1_HUMAN,CXA1_RAT,CXA1_CANLF,CXA1_BOVIN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | Cancer |
Gene Ensembl | ENSG00000152661 |
Target Classification | Tumor-associated antigen (TAA) |
The target: GJA1, gene name: GJA1, also named as AVSD3, CMDR, CX43, EKVP, EKVP3, GJAL, HLHS1, HSS, ODDD, PPKCA. This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations. [provided by RefSeq, May 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.