Anti-CXA1/ GJA1/ AVSD3 monoclonal antibody

Anti-CXA1/ GJA1/ AVSD3 antibody for FACS & in-vivo assay

Target products collectionGo to GJA1/GJA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T44479-Ab-1/ GM-Tg-hg-T44479-Ab-2Anti-Human GJA1 monoclonal antibodyHuman
GM-Tg-rg-T44479-Ab-1/ GM-Tg-rg-T44479-Ab-2Anti-Rat GJA1 monoclonal antibodyRat
GM-Tg-mg-T44479-Ab-1/ GM-Tg-mg-T44479-Ab-2Anti-Mouse GJA1 monoclonal antibodyMouse
GM-Tg-cynog-T44479-Ab-1/ GM-Tg-cynog-T44479-Ab-2Anti-Cynomolgus/ Rhesus macaque GJA1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T44479-Ab-1/ GM-Tg-felg-T44479-Ab-2Anti-Feline GJA1 monoclonal antibodyFeline
GM-Tg-cang-T44479-Ab-1/ GM-Tg-cang-T44479-Ab-2Anti-Canine GJA1 monoclonal antibodyCanine
GM-Tg-bovg-T44479-Ab-1/ GM-Tg-bovg-T44479-Ab-2Anti-Bovine GJA1 monoclonal antibodyBovine
GM-Tg-equg-T44479-Ab-1/ GM-Tg-equg-T44479-Ab-2Anti-Equine GJA1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T44479-Ab-1/ GM-Tg-hg-T44479-Ab-2; GM-Tg-rg-T44479-Ab-1/ GM-Tg-rg-T44479-Ab-2;
GM-Tg-mg-T44479-Ab-1/ GM-Tg-mg-T44479-Ab-2; GM-Tg-cynog-T44479-Ab-1/ GM-Tg-cynog-T44479-Ab-2;
GM-Tg-felg-T44479-Ab-1/ GM-Tg-felg-T44479-Ab-2; GM-Tg-cang-T44479-Ab-1/ GM-Tg-cang-T44479-Ab-2;
GM-Tg-bovg-T44479-Ab-1/ GM-Tg-bovg-T44479-Ab-2; GM-Tg-equg-T44479-Ab-1/ GM-Tg-equg-T44479-Ab-2
Products NameAnti-GJA1 monoclonal antibody
Formatmab
Target NameGJA1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-GJA1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CXA1/ GJA1/ AVSD3 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLV000455human GJA1 Lentivirus plasmid
    ORF Viral VectorvGMLV000455human GJA1 Lentivirus particle
    ORF Viral VectorpGMAP000184Human GJA1 Adenovirus plasmid
    ORF Viral VectorvGMAP000184Human GJA1 Adenovirus particle
    ORF Viral VectorpGMLP001348human NM_000165humanNM_000165 Lentivirus plasmid
    ORF Viral VectorvGMLP001348human NM_000165humanNM_000165 Lentivirus particle
    ORF Viral VectorpGMLV000150mouse Gja1 Lentivirus plasmid
    ORF Viral VectorpGMAD000534house mouse Gja1 Adenovirus plasmid
    ORF Viral VectorvGMLV000150mouse Gja1 Lentivirus particle
    ORF Viral VectorvGMAD000534house mouse Gja1 Adenovirus particle


    Target information

    Target IDGM-T44479
    Target NameGJA1
    Gene ID2697,14609,24392,714344,403418,101100211,281193,100067229
    Gene Symbol and SynonymsAVSD3,CMDR,Cnx43,connexin43,CX43,Cx43alpha1,Cxnk1,EKVP,EKVP3,Gja-1,GJA1,GJAL,HLHS1,HSS,Npm1,ODDD,PPKCA
    Uniprot AccessionP17302,P08050,Q6S9C0,P18246
    Uniprot Entry NameCXA1_HUMAN,CXA1_RAT,CXA1_CANLF,CXA1_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000152661
    Target ClassificationTumor-associated antigen (TAA)

    The target: GJA1, gene name: GJA1, also named as AVSD3, CMDR, CX43, EKVP, EKVP3, GJAL, HLHS1, HSS, ODDD, PPKCA. This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations. [provided by RefSeq, May 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.