TNFRSF18: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD

It's the GeneMedi's summary page for Target/Biomarker Introduction of TNFRSF18. The page also collects GeneMedi's different modalities and formats products for TNFRSF18 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the TNFRSF18 target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Transmembrane Protein.

This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]

Target ID	GM-T15344
Target Name	TNFRSF18
Gene ID	8784,21936,500598,699559,606971,101083251,516256,100066195
Gene Symbol and Synonyms	AITR,CD357,ENERGEN,GITR,GITR-D,TNFRSF18
Uniprot Accession	Q9Y5U5
Uniprot Entry Name	TNR18_HUMAN
Protein Sub-location	Transmembrane Protein
Category	Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
Disease	N/A
Gene Ensembl	ENSG00000186891
Target Classification	Checkpoint-Immuno Oncology

Pre-made TNFRSF18-specific INN-index biosimilar (antibody&conjugates)

Anti-TNFRSF18 therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).

Cat No.	Products Name (INN Index)	INN Name	Previous Name	Target	Format	Detail
GMP-Bios-ab-466	Pre-Made Ragifilimab biosimilar, Whole mAb, Anti-TNFRSF18 Antibody: Anti-AITR/CD357/ENERGEN/GITR/GITR-D therapeutic antibody	Ragifilimab		TNFRSF18	Whole mAb	Detail
GMP-Bios-INN-810	Pre-Made Efaprinermin Alfa Biosimilar, Fusion Protein targeting TNFRSF18 fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting AITR/CD357/ENERGEN/GITR/GITR-D	efaprinermin alfa		TNFRSF18	Fusion Protein	Detail
GMP-Bios-INN-815	Pre-Made Efgivanermin Alfa Biosimilar, Fusion Protein targeting TNFRSF18 fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting AITR/CD357/ENERGEN/GITR/GITR-D	efgivanermin alfa		TNFRSF18	Fusion Protein	Detail

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Pre-made anti-TNFRSF18 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-TNFRSF18 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-TNFRSF18 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Antibody Name	Species	Format	Classified by tag	Detail
Anti-TNFRSF18 monoclonal antibody	Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine	mab	FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody	Detail

Multi-species TNR18/ TNFRSF18/ AITR VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TNFRSF18 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Products Name	Species	Expression Platform	Detail
TNFRSF18 VLP (virus-like particle)	Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine	Mammalian cell	Products Developing

Cytokine Products for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse tumor necrosis factor receptor superfamily, member 18 (TNFRSF18) His+Avi (Biotinylated) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Tumor necrosis factor receptor superfamily member 18 (TNFRSF18) also known as activation-inducible TNFR family receptor (AITR) or glucocorticoid-induced TNFR-related protein (GITR) is a protein that in humans is encoded by the TNFRSF18 gene. GITR is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule.

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Detail
TNFRSF18	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor receptor superfamily, member 18 (TNFRSF18) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFRSF18 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).	Detail

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Pre-made TNFRSF18 viral vector in GM Promise-ORF^TM

Cat No.	Products name	NM ID	Species	Type	Detail
vGMLP000991	human TNFRSF18 Lentivirus particle	NM_004195	Human	Lentivirus particle	Detail
pGMLP000991	human TNFRSF18 Lentivirus plasmid	NM_004195	Human	Lentivirus plasmid	Detail
pGMLPm000528	mouse Tnfrsf18 Lentivirus plasmid	NM_009400	Mouse	Lentivirus plasmid	Detail
vGMLPm000528	mouse Tnfrsf18 Lentivirus particle	NM_009400	Mouse	Lentivirus particle	Detail

About Promise-ORF^TM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORF^TM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORF^TM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI

If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.