Anti-TNR18/ TNFRSF18/ AITR monoclonal antibody

Anti-TNR18/ TNFRSF18/ AITR antibody for FACS & in-vivo assay

Target products collectionGo to TNFRSF18/TNFRSF18 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T15344-Ab-1/ GM-Tg-hg-T15344-Ab-2Anti-Human TNFRSF18 monoclonal antibodyHuman
GM-Tg-rg-T15344-Ab-1/ GM-Tg-rg-T15344-Ab-2Anti-Rat TNFRSF18 monoclonal antibodyRat
GM-Tg-mg-T15344-Ab-1/ GM-Tg-mg-T15344-Ab-2Anti-Mouse TNFRSF18 monoclonal antibodyMouse
GM-Tg-cynog-T15344-Ab-1/ GM-Tg-cynog-T15344-Ab-2Anti-Cynomolgus/ Rhesus macaque TNFRSF18 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T15344-Ab-1/ GM-Tg-felg-T15344-Ab-2Anti-Feline TNFRSF18 monoclonal antibodyFeline
GM-Tg-cang-T15344-Ab-1/ GM-Tg-cang-T15344-Ab-2Anti-Canine TNFRSF18 monoclonal antibodyCanine
GM-Tg-bovg-T15344-Ab-1/ GM-Tg-bovg-T15344-Ab-2Anti-Bovine TNFRSF18 monoclonal antibodyBovine
GM-Tg-equg-T15344-Ab-1/ GM-Tg-equg-T15344-Ab-2Anti-Equine TNFRSF18 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T15344-Ab-1/ GM-Tg-hg-T15344-Ab-2; GM-Tg-rg-T15344-Ab-1/ GM-Tg-rg-T15344-Ab-2;
GM-Tg-mg-T15344-Ab-1/ GM-Tg-mg-T15344-Ab-2; GM-Tg-cynog-T15344-Ab-1/ GM-Tg-cynog-T15344-Ab-2;
GM-Tg-felg-T15344-Ab-1/ GM-Tg-felg-T15344-Ab-2; GM-Tg-cang-T15344-Ab-1/ GM-Tg-cang-T15344-Ab-2;
GM-Tg-bovg-T15344-Ab-1/ GM-Tg-bovg-T15344-Ab-2; GM-Tg-equg-T15344-Ab-1/ GM-Tg-equg-T15344-Ab-2
Products NameAnti-TNFRSF18 monoclonal antibody
Formatmab
Target NameTNFRSF18
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TNFRSF18 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-466Pre-Made Ragifilimab biosimilar, Whole mAb, Anti-TNFRSF18 Antibody: Anti-AITR/CD357/ENERGEN/GITR/GITR-D therapeutic antibody
    BiosimilarGMP-Bios-INN-810Pre-Made Efaprinermin Alfa Biosimilar, Fusion Protein targeting TNFRSF18 fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting AITR/CD357/ENERGEN/GITR/GITR-D
    BiosimilarGMP-Bios-INN-815Pre-Made Efgivanermin Alfa Biosimilar, Fusion Protein targeting TNFRSF18 fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting AITR/CD357/ENERGEN/GITR/GITR-D
    Target AntigenProducts DevelopingMulti-species TNR18/ TNFRSF18/ AITR VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T15344-Ag-1tumor necrosis factor receptor superfamily, member 18 (TNFRSF18) protein
    ORF Viral VectorvGMLP000991human TNFRSF18 Lentivirus particle
    ORF Viral VectorpGMLP000991human TNFRSF18 Lentivirus plasmid
    ORF Viral VectorpGMLPm000528mouse Tnfrsf18 Lentivirus plasmid
    ORF Viral VectorvGMLPm000528mouse Tnfrsf18 Lentivirus particle


    Target information

    Target IDGM-T15344
    Target NameTNFRSF18
    Gene ID8784,21936,500598,699559,606971,101083251,516256,100066195
    Gene Symbol and SynonymsAITR,CD357,ENERGEN,GITR,GITR-D,TNFRSF18
    Uniprot AccessionQ9Y5U5
    Uniprot Entry NameTNR18_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
    DiseaseN/A
    Gene EnsemblENSG00000186891
    Target ClassificationCheckpoint-Immuno Oncology

    The target: TNFRSF18, gene name: TNFRSF18, also named as AITR, CD357, GITR, GITR-D. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.