TIMP1: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of TIMP1. The page also collects GeneMedi's different modalities and formats products for TIMP1 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the TIMP1 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Secreted Protein/Potential Cytokines.
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]
Target ID | GM-SE0506 |
Target Name | TIMP1 |
Gene ID | 7076,21857,116510,574348,403816,101095886,282092,100034220 |
Gene Symbol and Synonyms | CLGI,EPA,EPO,HCI,TIMP,TIMP-1,TIMP1,TPA-S1 |
Uniprot Accession | P01033,P30120,Q95KL9,P81546,P20414,O02722 |
Uniprot Entry Name | TIMP1_HUMAN,TIMP1_MACMU,TIMP1_RAT,TIMP1_CANLF,TIMP1_BOVIN,TIMP1_HORSE |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category | Diagnostics Biomarker |
Disease | Dent disease, Vesicoureteral reflux |
Gene Ensembl | ENSG00000102265 |
Target Classification | N/A |
Pre-made anti-TIMP1 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-TIMP1 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-TIMP1 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Antibody Name | Species | Format | Classified by tag | Detail |
Anti-TIMP1 monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | FACS/Biofunctional Antibody, Diagnostic target antibody | Detail |
Recombinant multi-species TIMP1/ CLGI/ EPA protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TIMP1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Products Name | Species | Expression Platform | Detail |
TIMP1 protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made TIMP1 viral vector in GM Promise-ORFTM
Cat No. | Products name | NM ID | Species | Type | Detail |
vGMAP000469 | Human TIMP1 Adenovirus particle | BC000866 | Human | Adenovirus particle | Detail |
pGMAP000553 | Human TIMP1 Adenovirus plasmid | BC000866 | Human | Adenovirus plasmid | Detail |
pGMAP000455 | Human TIMP1 Adenovirus plasmid | BC000866 | Human | Adenovirus plasmid | Detail |
vGMAP000455 | Human TIMP1 Adenovirus particle | BC000866 | Human | Adenovirus particle | Detail |
vGMAP000553 | Human TIMP1 Adenovirus particle | BC000866 | Human | Adenovirus particle | Detail |
pGMLV000257 | human TIMP1 Lentivirus plasmid | NM_003254.2 | Human | Lentivirus plasmid | Detail |
pGMAP000469 | Human TIMP1 Adenovirus plasmid | BC000866 | Human | Adenovirus plasmid | Detail |
vGMLV000257 | human TIMP1 Lentivirus particle | NM_003254.2 | Human | Lentivirus particle | Detail |
pGMLP001347 | human NM_003254humanNM_003254 Lentivirus plasmid | NM_003254 | Human | Lentivirus plasmid | Detail |
vGMLP001347 | human NM_003254humanNM_003254 Lentivirus particle | NM_003254 | Human | Lentivirus particle | Detail |
pGMLPm000328 | mouse Timp1 Lentivirus plasmid | NM_011593 | Mouse | Lentivirus plasmid | Detail |
vGMLPm000328 | mouse Timp1 Lentivirus particle | NM_011593 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.